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Titolo:
Uptake of apoptotic leukocytes by synovial lining macrophages inhibits immune complex-mediated arthritis
Autore:
van Lent, PLEM; Licht, R; Dijkman, H; Holthuysen, AEM; Berden, JHM; van den Berg, WB;
Indirizzi:
Univ Nijmegen, Med Ctr, Div Rheumatol, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands Univ Nijmegen, Med Ctr, Div Nephrol, NL-6500 HB Nijmegen, Netherlands UnivNijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands Univ Nijmegen, Med Ctr, Div Pathol, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 5, volume: 70, anno: 2001,
pagine: 708 - 714
SICI:
0741-5400(200111)70:5<708:UOALBS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEATH; IN-VITRO; POLYMORPHONUCLEAR LEUKOCYTES; MEMBRANE PHOSPHATIDYLSERINE; PERITONEAL-MACROPHAGES; VITRONECTIN RECEPTOR; CYTOKINE PRODUCTION; PHAGOCYTOSIS; RECOGNITION; INFLAMMATION;
Keywords:
joint inflammation; immune complexes; synovium; apoptotic cells; synovial lining macrophages; chemotaxis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: van Lent, PLEM Univ Nijmegen, Med Ctr, Div Rheumatol, Geert Grooteplein 26-28, NL-6500 HBNijmegen, Netherlands Univ Nijmegen Geert Grooteplein 26-28 Nijmegen Netherlands NL-6500 HB
Citazione:
P.L.E.M. van Lent et al., "Uptake of apoptotic leukocytes by synovial lining macrophages inhibits immune complex-mediated arthritis", J LEUK BIOL, 70(5), 2001, pp. 708-714

Abstract

Previously we have shown that synovial lining macrophages (SLMs) determinethe onset of experimental immune complex-mediated arthritis (ICA). During joint inflammation, many leukocytes undergo apoptosis, and removal of leukocytes by SLMs may regulate resolution of inflammation. In this study we investigated binding and uptake of apoptotic leukocytes by SLMs and its impacton the onset of murine experimental arthritis. We used an in vitro model to evaluate phagocytosis of apoptotic cells on chemotaxis. Phagocytosis of apoptotic thymocytes resulted in a significant decrease (58%) of chemotacticactivity for polymorphonuclear neutrophils (PMNs). If apoptotic cells wereinjected directly into a normal murine knee joint, SLMs resulted in a prominent uptake of cells. After ICA induction, electron micrographs showed that apoptotic leukocytes were evidently present in SLMs on days 1 and 2. Injection of apoptotic leukocytes into the knee joint 1 h before induction of ICA significantly inhibited PMN infiltration into the knee joint at 24 h (61% decrease). This study indicates that uptake of apoptotic leukocytes by SLM reduces chemotactic activity and inhibits the onset of experimental arthritis. These findings indicate an important mechanism in the resolution of joint inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:55:51