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Titolo:
Skin test results but not serology reflect immediate type respiratory sensitivity: A study performed with recombinant allergen molecules
Autore:
Niederberger, V; Stubner, P; Spitzauer, S; Kraft, D; Valenta, R; Ehrenberger, K; Horak, F;
Indirizzi:
Univ Vienna, AKH, Dept Pathophysiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Pathophysiol, A-1090 Vienna, Austria Univ Vienna, AKH, Dept Otorhinolaryngol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 orhinolaryngol, A-1090 Vienna, Austria Univ Vienna, AKH, Inst Med & Chem Lab Diagnost, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 m Lab Diagnost, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 4, volume: 117, anno: 2001,
pagine: 848 - 851
SICI:
0022-202X(200110)117:4<848:STRBNS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRASS PHLEUM-PRATENSE; FC-EPSILON-RI; BIRCH POLLEN ALLERGEN; HIGH-LEVEL EXPRESSION; IGE ANTIBODY; HUMAN BASOPHILS; MAJOR ALLERGEN; PURIFICATION; PROVOCATION; DIAGNOSIS;
Keywords:
diagnosis; IgE; nasal provocation test; recombinant allergen; rhinomanometry; skin prick test; type I allergy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Valenta, R Univ Vienna, AKH, Dept Pathophysiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna AustriaA-1090 ria
Citazione:
V. Niederberger et al., "Skin test results but not serology reflect immediate type respiratory sensitivity: A study performed with recombinant allergen molecules", J INVES DER, 117(4), 2001, pp. 848-851

Abstract

The diagnosis of type I allergy, an IgE-antibody-mediated hypersensitivitydisease affecting more than 25% of the population, is based on the measurement of allergen-specific serum IgE levels and provocation testing. Whetherthe determination of allergen-specific serum IgE levels can replace in vivo provocation testing for allergy diagnosis is a controversial issue. We used purified recombinant timothy grass and birch pollen allergens to compareby skin prick and nasal provocation testing as well as by serology in vivosensitivity with antibody-binding capacity in 24 pollen allergic patients and eight control individuals. Results from biologic tests were correlated with each other and with allergen-specific IgE and IgG(1-4) levels. IgE-reactive allergens induced immediate skin and nasal reactions, but the intensity of the allergic tissue reactions was not correlated with either the levels of allergen-specific IgE or the levels of allergen-specific IgG antibodies. Less frequently detected allergens with low IgE-binding capacity were able to induce strong allergic reactions comparable to those caused by majorallergens with high IgE-binding capacity. In contrast, skin test and nasalprovocation results were significantly correlated (r = 0.63, p < 0.01). Our study thus demonstrates on a molecular level that skin testing provides abetter reflection of immediate type respiratory sensitivity than serologicmeasurements. These results have implications for allergy diagnosis and, in particular, for the selection of relevant allergen components for specific immunotherapy.

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Documento generato il 07/04/20 alle ore 03:56:10