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Titolo:
Independent and synergistic effects of interleukin-18 and interleukin-12 in augmenting cytotoxic T lymphocyte responses and IFN-gamma production in aging
Autore:
Zhang, YX; Wang, Y; Gilmore, X; Xu, KY; Mbawuike, IN;
Indirizzi:
Baylor Coll Med, Dept Microbiol & Immunol, Influenza Res Ctr, Resp Pathogens Res Unit, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 gens Res Unit, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
fascicolo: 10, volume: 21, anno: 2001,
pagine: 843 - 850
SICI:
1079-9907(200110)21:10<843:IASEOI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLUENZA-A VIRUS; NATURAL-KILLER-CELLS; IL-18 RECEPTOR; CYTOKINE PRODUCTION; MESSENGER-RNA; CUTTING EDGE; TH2 CELLS; MICE; EXPRESSION; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Mbawuike, IN Baylor Coll Med, Dept Microbiol & Immunol, Influenza Res Ctr,Resp Pathogens Res Unit, Houston, TX 77030 USA Baylor Coll Med Houston TXUSA 77030 , Houston, TX 77030 USA
Citazione:
Y.X. Zhang et al., "Independent and synergistic effects of interleukin-18 and interleukin-12 in augmenting cytotoxic T lymphocyte responses and IFN-gamma production in aging", J INTERF CY, 21(10), 2001, pp. 843-850

Abstract

Aged mice exhibit diminished CD8(+) cytotoxic T lymphocyte (CTL) response to influenza virus. Previously, interleukin-12 (IL-12) was shown to partially restore in vitro influenza virus-specific CD8(+) CTL activity and interferon-gamma (IFN-gamma) production in aged mice. The present study investigated IL-18 production and its ability to collaborate with IL-12 to enhance these responses to the levels of young mice. IL-18 protein production and mRNA expression in influenza virus-specific CTL from aged mice were higher than from young mice. In contrast, IL-18 receptor (IL-18R) mRNA expression was significantly reduced in CD8(+) CTL from aged mice. Generation of CTL in the presence of IL-12 alone caused a significant increase in IFN-gamma production in both old and young mice. IL-18 treatment alone significantly increased IFN-gamma in CTL from young but not old mice. However, a combination of IL-18 and IL-12 significantly increased IFN-gamma in both old and young mice. IL-18 and IL-12, either alone or in combination, stimulated significant influenza virus-specific cytotoxicity in both old and young mice, but nosignificant synergistic effect was observed. These results represent an initial demonstration of downregulated IL-18R expression in aging mice and are consistent with age-related cytotoxic T lymphocyte 1 (Tc1) deficiency. Potentially, IL-18 and IL-12 can augment IFN-gamma production and reverse CD8(+) CTL deficiency in aging, independently or synergistically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:03:21