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Titolo:
Growth inhibition of Candida albicans by human vaginal epithelial cells
Autore:
Barousse, MM; Steele, C; Dunlap, K; Espinosa, T; Boikov, D; Sobel, JD; Fidel, PL;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Louisiana State Univ, Hlth Sci Ctr, Dept Obstet & Gynecol, New Orleans, LA70112 USA Louisiana State Univ New Orleans LA USA 70112 l, New Orleans, LA70112 USA Wayne State Univ, Sch Med, Div Infect Dis, Detroit, MI USA Wayne State Univ Detroit MI USA Sch Med, Div Infect Dis, Detroit, MI USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 11, volume: 184, anno: 2001,
pagine: 1489 - 1493
SICI:
0022-1899(200112)184:11<1489:GIOCAB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Fidel, PL Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 ans, LA 70112 USA
Citazione:
M.M. Barousse et al., "Growth inhibition of Candida albicans by human vaginal epithelial cells", J INFEC DIS, 184(11), 2001, pp. 1489-1493

Abstract

Vulvovaginal candidiasis (VVC) is a common mucosal infection caused by Candida species in women of childbearing age. Although acute VVC affects a large number of women and is often precipitated by hormonal fluctuations involving high estrogen levels, recurrent VVC (RVVC) affects another 5%-10% of women without any known predisposing factors. We have recently reported thatvaginal epithelial cells from nonhuman primates and mice inhibit the growth of Candida albicans in vitro, which may represent an innate host defense mechanism against C. albicans at the vaginal mucosa. In the present study, we show that vaginal epithelial cells collected from healthy women with no history of VVC also exhibit anti-Candida activity, with no differences in activity at various stages of the menstrual cycle. Women diagnosed with RVVC, on the other hand, have reduced epithelial cell anti-Candida activity. These results are further evidence that vaginal epithelial cells provide an innate host resistance mechanism against Candida and that reduced activity may contribute to RVVC.

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Documento generato il 03/07/20 alle ore 14:41:08