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Titolo:
Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versuschronic graft-versus-host disease
Autore:
Ogawa, S; Nagamatsu, G; Watanabe, M; Watanabe, S; Hayashi, T; Horita, S; Nitta, K; Nihei, H; Tezuka, K; Abe, R;
Indirizzi:
Sci Univ Tokyo, Res Inst Biol Sci, Div Immunobiol, Chiba 2780022, Japan Sci Univ Tokyo Chiba Japan 2780022 Div Immunobiol, Chiba 2780022, Japan JT Pharmaceut Frontier Res Labs Inc, Kanagawa, Japan JT Pharmaceut Frontier Res Labs Inc Kanagawa Japan Inc, Kanagawa, Japan Tokyo Womens Med Univ, Kidney Ctr, Dept Med, Tokyo, Japan Tokyo Womens MedUniv Tokyo Japan v, Kidney Ctr, Dept Med, Tokyo, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 10, volume: 167, anno: 2001,
pagine: 5741 - 5748
SICI:
0022-1767(20011115)167:10<5741:OEOALM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-HELPER CELL; TH2 CYTOKINE PRODUCTION; CD28 COSTIMULATION; IMMUNE-RESPONSES; CTLA4IG PREVENTS; MOLECULE ICOS; INHIBITS TH1; PROTEIN ICOS; CUTTING EDGE; OX40 LIGAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, R Sci Univ Tokyo, Res Inst Biol Sci, Div Immunobiol, 2669 Yamazaki, Chiba 2780022, Japan Sci Univ Tokyo 2669 Yamazaki Chiba Japan 2780022 ba 2780022, Japan
Citazione:
S. Ogawa et al., "Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versuschronic graft-versus-host disease", J IMMUNOL, 167(10), 2001, pp. 5741-5748

Abstract

The functional role of inducible costimulator (ICOS)-mediated costimulation was examined in an in vivo model of alloantigen-driven Th1 or Th2 cytokine responses, the parent-into-F-1 model of acute or chronic graft-vs-host disease (GVHD), respectively. When the Ab specific for mouse ICOS was injected into chronic GVHD-induced mice, activation of B cells, production of autoantibody, and development of glomerulonephritis were strongly suppressed. In contrast, the same treatment enhanced donor T cell chimerism and host B cell depletion in acute GVHD induced host mice. Blocking of B7-CD28 interaction by injection of anti-B7-1 and anti-B7-2 Abs inhibited both acute and chronic GVHD. These observations clearly indicate that the costimulatory signal mediated by CD28 caused the initial allorecognition resulting in the clonal expansion of alloreactive T cells, whereas the costimulatory signal mediated by ICOS played a critical role in the functional differentiation and manifestation of alloreactive T cells. Furthermore, treatment with anti-ICOS Ab selectively suppresses Th2-dominant autoimmune disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:22:24