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Titolo:
Determinants of mean arterial pressure and pulse pressure in chronic haemodialysis patients
Autore:
Abdelfatah, AB; Motte, G; Ducloux, D; Chalopin, JM;
Indirizzi:
St Jacques Hosp, Dept Nephrol Dialysis & Renal Transplantat, Besancon, France St Jacques Hosp Besancon France & Renal Transplantat, Besancon, France
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
fascicolo: 11, volume: 15, anno: 2001,
pagine: 775 - 779
SICI:
0950-9240(200111)15:11<775:DOMAPA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT-HUMAN-ERYTHROPOIETIN; STAGE RENAL-DISEASE; BLOOD-PRESSURE; CIGARETTE-SMOKING; HEMODIALYSIS-PATIENTS; HYPERTENSION; ENDOTHELIN-1; DIALYSIS; HYPERPARATHYROIDISM; MULTICENTER;
Keywords:
mean arterial pressure; pulse pressure; haemodialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ducloux, D St Jacques Hosp, Dept Nephrol Dialysis & Renal Transplantat, Besancon, France St Jacques Hosp Besancon France ansplantat, Besancon, France
Citazione:
A.B. Abdelfatah et al., "Determinants of mean arterial pressure and pulse pressure in chronic haemodialysis patients", J HUM HYPER, 15(11), 2001, pp. 775-779

Abstract

Hypertension is highly prevalent in the dialysis population, and has been implicated in the pathogenesis of the observed excess of cardiovascular morbidity and mortality in these patients. Nevertheless, there are no reports on the clinical and biochemical determinants of both pulse pressure (PP) and mean arterial pressure (MAP) in dialysis populations. A total of 541 haemodialysed patients from 11 dialysis centres were included in the study. Thedemographic, clinical, and biological characteristics were recorded. Both pre- and postdialytic blood pressures (systolic and diastolic) were measured. PP and MAP were calculated. Mean predialytic PP was 67 +/- 17 mm Hg and significantly decreased after dialysis (60 +/- 18 mm Hg; P < 0.0001). In multivariate analysis, a 10 mm Hg increase in PP was positively associated with age (RR, 2.01; 95% Cl, 1.35-5.01, for a 10-year increase in age), diabetes mellitus (RR, 1.08; 95% Cl, 1.04-1.14), interdialytic weight gain (IWG) (RR, 1.84; 95% Cl, 1.07-3.18, for 1% increase in IWG), and current smoking (RR, 2.59; 95% Cl, 1.13-5.92) and negatively with Hb concentration (RR, 0.92; 95% Cl, 0.84-0.99, for a 1 g/100 ml in Hb). Mean predialytic MAP was 98 /- 15 mm Hg and significantly decreased after dialysis (91 +/- 16 mm Hg; P< 0.0001). In multivariate, analysis, a 10 mm Hg increase in MAP was positively associated with parathyroid hormone (PTH) (RR, 1.32; 95% Cl, 1.15-1.6, for 50 ng/ml in PTH), erythropoietin (EPO) treatment (RR, 1.09; 95% Cl, 1.03-1.16), and current smoking (RR, 1.87; 95% Cl, 1.39-2.41). PP and MAP are associated with different clinical parameters. Most of these factors are potentially reversible. Smoking cessation, correction of anaemia and limitation of IWG should be important challenges for physicians in care of dialysis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:14:57