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Titolo:
Molecular and cell biological aspects of Alzheimer disease
Autore:
Shastry, BS;
Indirizzi:
Oakland Univ, Dept Biol Sci, Rochester, MI 48309 USA Oakland Univ Rochester MI USA 48309 ept Biol Sci, Rochester, MI 48309 USA
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 11, volume: 46, anno: 2001,
pagine: 609 - 618
SICI:
1434-5161(2001)46:11<609:MACBAO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; A-BETA PEPTIDE; ALPHA GENE POLYMORPHISMS; PAIRED HELICAL FILAMENTS; GAMMA-SECRETASE ACTIVITY; POPULATION-BASED SAMPLE; C-TERMINAL FRAGMENTS; APOLIPOPROTEIN-E; TRANSGENIC MICE; MOUSE MODEL;
Keywords:
Alzheimer disease; amyloid; presenilins; mutation; gene; oxidative stress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
182
Recensione:
Indirizzi per estratti:
Indirizzo: Shastry, BS Oakland Univ, Dept Biol Sci, Rochester, MI 48309 USA Oakland Univ Rochester MI USA 48309 , Rochester, MI 48309 USA
Citazione:
B.S. Shastry, "Molecular and cell biological aspects of Alzheimer disease", J HUM GENET, 46(11), 2001, pp. 609-618

Abstract

Alzheimer disease (AD) is one of several types of chronic and very common dementing disorders, affecting individuals aged 65 years or older. During the last five years, an enormous growth in the field has enriched our understanding of this complex condition. Molecular genetic studies have identified at least three genes that, when mutated. cause the autosomal dominant, early-onset familial form of the disease. The late-onset. most common forms of the disease are likely to be associated with various genetic susceptibility factors. The application of cell biological techniques has given insightinto basic aspects of the functions of important proteins involved in disease progression. and transgenic animal studies have further enriched our knowledge of the pathophysiological aspects of the disease. More efficient therapeutic drugs to retard its progression have been developed, as well as techniques to identify the preclinical phase of the disorder. Although we are st ill lacking the molecular basis and order of events involved in the disease process, the future for AD research, as well as for AD patients, is more promising than ever before.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:04:51