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Titolo:
DEVELOPMENT AND CHARACTERIZATION OF AN ALGINATE-IMPREGNATED POLYESTERVASCULAR GRAFT
Autore:
LEE JH; KIM WG; KIM SS; LEE JH; LEE HB;
Indirizzi:
HANNAM UNIV,DEPT MACROMOL SCI,133 OJEONG DONG TAEJON 306791 SOUTH KOREA SEOUL NATL UNIV HOSP,DEPT THORAC & CARDIOVASC SURG SEOUL 110744 SOUTHKOREA KOREA RES INST CHEM TECHNOL,BIOMAT LAB TAEJON 305606 SOUTH KOREA KYUNG HEE UNIV HOSP,COLL MED,DEPT PATHOL SEOUL 130702 SOUTH KOREA
Titolo Testata:
Journal of biomedical materials research
fascicolo: 2, volume: 36, anno: 1997,
pagine: 200 - 208
SICI:
0021-9304(1997)36:2<200:DACOAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEXTILE ARTERIAL PROSTHESES; KNITTED DACRON; BIOLOGICAL SEALANTS; CALCIUM-ALGINATE; THORACIC AORTA; FIBRIN GLUE; COLLAGEN; ALBUMIN; POROSITY; SUBSTITUTES;
Keywords:
VASCULAR GRAFT; POLYESTER; POROSITY; ALGINATE IMPREGNATION; BLOOD-LEAK PREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Lee et al., "DEVELOPMENT AND CHARACTERIZATION OF AN ALGINATE-IMPREGNATED POLYESTERVASCULAR GRAFT", Journal of biomedical materials research, 36(2), 1997, pp. 200-208

Abstract

Alginate gels are known to be biocompatible, degradable, and nontoxic. In this study, sodium alginate was impregnated into a porous, knitted polyester graft (Microvel(R) double velour graft) 6 mm in diameter. The alginate-impregnated graft was investigated in vitro and in vivo to evaluate its potential for use as a new vascular graft impervious toblood, while retaining high porosity for tissue ingrowth and biological healing. For in vitro investigation, the coating weight, water permeability, morphology, and mechanical properties of the alginate-impregnated grafts were compared to those of control or commercially available collagen-impregnated (Hemashield(R)) grafts. The water permeabilityof the controls (1846 mL/min.cm(2) at 120 mm Hg) was reduced >99% by the alginate impregnation, rendering the graft impervious to blood. The coating weight of the alginate was 45 mg/g of graft, producing a much lower value than that of the collagen-impregnated model (310 mg/g). For in vivo investigation, the alginate-impregnated grafts were implanted in the aorta of mongrel dogs without preclotting for scheduled periods ranging from 4 h to 6 months. The control grafts after preclotting and the collagen-impregnated grafts without preclotting were also implanted for 3 and 6 months for comparison. Gross observation of the explanted grafts and histologic examination of the representative sections were conducted for three types of grafts using a light microscope after hematoxylin-eosin staining. No significant differences were observed between the histologic appearance of the alginate-impregnated grafts and that of the preclotted and collagen-impregnated grafts in termsof the degree of inflammation, foreign-body giant cell reaction, and intimal fibrosis. Endothelial-like cells were present on the midsections of all the grafts after 3 months of implantation The resorption rate of alginate impregnated into the graft was also examined after staining the sections with periodic acid-Schiff reagent, Toluidine blue, and Alcian blue, which are specific for alginates. The staining alginatewas partially visible between the graft fabrics up to 1 month after implantation, but was completely resorbed after 3 months. This preliminary study demonstrated that the use of an alginate as a biological sealant instead of proteins such as collagen, gelatin, and albumin may bea feasible approach to developing imprevious textile arterial prostheses, since the proteins have been reported to be generally unstable, hard to obtain in pure forms, not easy to crosslink and control resorption rate, and difficult to render compatible with standard storage andsterilization procedures. (C) 1997 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:38:45