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Titolo:
Evaluation of chronic urticaria in patients with hashimoto thyroiditis
Autore:
Kandeel, AA; Zeid, M; Helm, T; Lillie, MA; Donahue, E; Ambrus, JL;
Indirizzi:
Kaleida Hlth Buffalo Gen Hosp, Dept Med, Div Allergy Immunol & Rheumatol, Buffalo, NY 14203 USA Kaleida Hlth Buffalo Gen Hosp Buffalo NY USA 14203 Buffalo, NY 14203 USA Kaleida Hlth Buffalo Gen Hosp, Dept Pathol, Buffalo, NY 14203 USA Kaleida Hlth Buffalo Gen Hosp Buffalo NY USA 14203 Buffalo, NY 14203 USA Kaleida Hlth Millard Fillmore Hosp, Dept Allergy, Buffalo, NY 14203 USA Kaleida Hlth Millard Fillmore Hosp Buffalo NY USA 14203 alo, NY 14203 USA
Titolo Testata:
JOURNAL OF CLINICAL IMMUNOLOGY
fascicolo: 5, volume: 21, anno: 2001,
pagine: 335 - 347
SICI:
0271-9142(200109)21:5<335:EOCUIP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC IDIOPATHIC URTICARIA; FC-EPSILON-RI; AFFINITY IGE RECEPTOR; ANTI-IGE; T-CELL; AUTOIMMUNE-THYROIDITIS; B-CELLS; AUTOANTIBODIES; ASSOCIATION; ANGIOEDEMA;
Keywords:
urticaria; autoimmunity; Hashimoto thyroiditis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ambrus, JL SUNY Buffalo, Sch Med & Biomed Sci, MultiLab Res Bldg,Room 108,100 High St, Buffalo, NY 14203 USA SUNY Buffalo MultiLab Res Bldg,Room 108,100 High St Buffalo NY USA 14203
Citazione:
A.A. Kandeel et al., "Evaluation of chronic urticaria in patients with hashimoto thyroiditis", J CLIN IMM, 21(5), 2001, pp. 335-347

Abstract

The coincidence of Hashimoto thyroiditis (HT) and chronic idiopathic urticaria (CIU) is a commonly observed phenomenon in western New York. Previous literature suggested that there may be a direct relationship between them. We undertook these studies to determine whether humoral or cell-mediated mechanisms might link HT and CIU. Skin biopsies from patients with CIU, with or without HT, were indistinguishable by light microscopy. No immune complex deposition was observed, although only the skin from patients with CIU and HT contained perivascular fibrin deposits. Similarly, inummohistochemical studies evaluating cellular expression of CD3, CD4, CD8, CD20, and CD68 failed to differentiate between CIU with or without HT. Analysis of VG restriction in thyroid tissue of patients with HT and the skin of patients with CIU and HT by in situ polymerasechain reaction failed to reveal any oligoclonal T-lymphocyte subpopulations. In contrast, only patients with CIU and HT had anti-Fc epsilon RI antibodies in their sera that could induce degranulation of normal basophils. Some sera from patients with CIU and HT caused degranulation of normal basophils in the absence of anti-FceRI. The factor causing basophil degranulation in these sera was not determined. Patients with CIU and HT failed to improve clinically with thyroid replacement therapy. All CIU patients were equally well managed with symptomatic therapies. In conclusion, HT likely represents a marker of other autoimmunity, ratherthan being a direct causative agent in CIU. Management of CIU, with or without HT and with or without anti-FceRI antibodies, should be the same. Future studies will have to examine whether cell-mediated responses participatein CIU, especially in association with HT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:00:51