Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mechanisms of cell-mediated myocytotoxicity in the peripheral blood of patients with inflammatory myopathies
Autore:
Bank, I; Miranda, AF; Chess, L;
Indirizzi:
Chaim Sheba Med Ctr, Dept Med F, IL-52621 Tel Hashomer, Israel Chaim ShebaMed Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Tel Aviv Univ, Sch Med, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 IL-52621 Tel Hashomer, Israel Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY USA Columbia Univ New York NY USA Phys & Surg, Dept Neurol, New York, NY USA Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY USA Columbia UnivNew York NY USA ll Phys & Surg, Dept Med, New York, NY USA
Titolo Testata:
JOURNAL OF CLINICAL IMMUNOLOGY
fascicolo: 5, volume: 21, anno: 2001,
pagine: 328 - 334
SICI:
0271-9142(200109)21:5<328:MOCMIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-CELLS; MUSCLE CULTURES; CYTO-TOXICITY; LIGAND INTERACTION; MONONUCLEAR-CELLS; POLYMYOSITIS; DERMATOMYOSITIS; INTERLEUKIN-2; QUANTITATION; PATHOGENESIS;
Keywords:
inflammatory myopathy; polymyositis; dermatomyositis; T cells; myotubes; cytotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Bank, I Chaim Sheba Med Ctr, Dept Med F, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 ashomer, Israel
Citazione:
I. Bank et al., "Mechanisms of cell-mediated myocytotoxicity in the peripheral blood of patients with inflammatory myopathies", J CLIN IMM, 21(5), 2001, pp. 328-334

Abstract

Cell-mediated cytotoxicity is thought to play an important role in the immunopathogenesis of inflammatory myopathies. We determined whether lymphocytes circulating in patient peripheral blood contain automyocytotoxic precursors. Peripheral blood mononuclear cells, sheep red blood cell rosetting (E+) and nonrosetting (E-) cells, were isolated from patients with polymyositis or dermatomyositis and tested for their ability to kill autologous-cultured myotubes derived from diseased muscle biopsies. Patient-derived as well as normal allogeneic mononuclear cells lysed both polymyositis-dermatomyositis and nonrelated myotubes. However, whereas patient E+ cells were preferentially cytotoxic to autologous myotubes, their E- cells did not discriminate autologous from allogeneic targets. Furthermore, cultures of patient E+ cells triggered by phytohemagglutinin and interleukin-2 maintained myocytotoxic potential. In these cultures, virtually all autologous but only 50% ofallogeneic killing was mediated by CD3(+) T cells. Moreover, autologous cell-mediated killing was abrogated by anti-CD3 monoclonal antibodies. In conclusion, both myocytotoxic CD3(+) T-cell clones specific for autologous myotubes, as well as non-T cells, which are nonspecifically myocytotoxic, are present in the peripheral blood of patients with inflammatory myopathies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:35:10