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Titolo:
Evidence for spatial heterogeneity in insulin-and exercise-induced increases in glucose uptake: Studies in normal subjects and patients with type 1 diabetes
Autore:
Peltoniemi, P; Yki-Jarvinen, H; Laine, H; Oikonen, V; Ronnemaa, T; Kalliokoski, K; Raitakari, O; Knuuti, MJ; Nuutila, P;
Indirizzi:
Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 rku PET Ctr, FIN-20520 Turku, Finland Univ Turku, Dept Med, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 u, Dept Med, FIN-20520 Turku, Finland Univ Helsinki, Dept Med, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ed, FIN-00014 Helsinki, Finland
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 11, volume: 86, anno: 2001,
pagine: 5525 - 5533
SICI:
0021-972X(200111)86:11<5525:EFSHII>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; POSITRON-EMISSION-TOMOGRAPHY; FLUORO-DEOXY-GLUCOSE; BLOOD-FLOW; LUMPED CONSTANT; FIBER TYPE; F-18 FLUORODEOXYGLUCOSE; CAPILLARY RECRUITMENT; IN-VIVO; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Peltoniemi, P Univ Turku, Turku PET Ctr, POB 52, FIN-20520 Turku, Finland Univ Turku POB 52 Turku Finland FIN-20520 20 Turku, Finland
Citazione:
P. Peltoniemi et al., "Evidence for spatial heterogeneity in insulin-and exercise-induced increases in glucose uptake: Studies in normal subjects and patients with type 1 diabetes", J CLIN END, 86(11), 2001, pp. 5525-5533

Abstract

It is unknown whether resistance to insulin- or exercise-stimulated glucose uptake reflects a spatially uniform or nonuniform decrease in glucose uptake within skeletal muscle. We compared the distributions of muscle glucoseuptake and blood flow in eight patients with type 1 diabetes (age 24 +/- 1yr, body mass index 22.0 +/- 0.8 kg/m(2)) and seven age- and weight-matched normal subjects using positron emission tomography, [F-18]-fluoro-deoxy-glucose, and [O-15]-water. Both groups were studied during euglycemic hyperinsulinemia and one-legged exercise. Heterogeneity was evaluated by calculating relative dispersion (SD divided by mean * 100%) of glucose uptake (RDg)and flow (RDf) in all pixels within a region of interest in femoral muscle. At rest insulin-stimulated glucose uptake was significantly lower in the type 1 diabetic patients (42 +/- 7 mu mol/kg per min) than in the normal subjects (78 +/- 9 mu mol/kg per min, P < 0.001), while muscle blood flows were similar (26 +/- 1 vs. 31 +/- 3 ml/kg muscle per min, respectively). The exercise-induced increment in glucose uptake but not in blood flow was alsosignificantly lower in the type 1 diabetic patients than in the normal subjects. Heterogeneity of glucose uptake but not of blood flow was greater inthe insulin-resistant type 1 diabetic patients both at rest (RD 31 +/- 1 vs. 25 +/- 2%, patients with type 1 diabetes vs. normal subjects, P < 0.05) and during exercise, compared with normal subjects (27 +/- 1 vs. 21 +/- 2%,respectively, P < 0.05). Exercise increased both glucose uptake and blood flow several-fold and significantly decreased both RDg and RDf. Heterogeneity of RDg, was inversely associated with total glucose uptake (r = -0.54, P< 0.001, pooled data) and was highest in the most insulin-resistant patients. We concluded that both glucose uptake and blood flow are characterized by heterogeneity in human skeletal muscle, whose magnitude is inversely proportional to respective mean values: This implies that an increase in glucose uptake in human skeletal muscle is not a phenomenon, by which each unit increases its glucose uptake by a fixed amount but rather a spatially heterogeneous process.

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Documento generato il 25/01/20 alle ore 19:33:15