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Titolo:
Evidence for genetic factors explaining the association between birth weight and low-density lipoprotein cholesterol and possible intrauterine factors influencing the association between birth weight and high-density lipoprotein cholesterol: Analysis in twins
Autore:
Ijzerman, RG; Stehouwer, CDA; Van Weissenbruch, MM; De Geus, EJ; Boomsma, DI;
Indirizzi:
Vrije Univ Amsterdam, Acad Hosp, Dept Paediat, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Acad Hosp, Inst Endocrinol Reprod & Metab, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Dept Internal Med, NL-1007 MB Amsterdam, NetherlandsVrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Inst Cardiovasc Res, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Dept Biol Psychol, NL-1007 MB Amsterdam, NetherlandsVrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 11, volume: 86, anno: 2001,
pagine: 5479 - 5484
SICI:
0021-972X(200111)86:11<5479:EFGFET>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; INSULIN-RESISTANCE SYNDROME; CARDIOVASCULAR RISK-FACTORS; APOLIPOPROTEIN-A-I; BLOOD-PRESSURE; FETAL ORIGINS; SWEDISH MEN; PLASMA; GROWTH; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Stehouwer, CDA Vrije Univ Amsterdam, Acad Hosp, Dept Med, De Boelelaan 1117,POB 7057, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam De Boelelaan 1117,POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
R.G. Ijzerman et al., "Evidence for genetic factors explaining the association between birth weight and low-density lipoprotein cholesterol and possible intrauterine factors influencing the association between birth weight and high-density lipoprotein cholesterol: Analysis in twins", J CLIN END, 86(11), 2001, pp. 5479-5484

Abstract

Recent studies have demonstrated an association between low weight at birth and an atherogenic lipid profile in later life. To examine the influencesof intrauterine and genetic factors, we investigated 53 dizygotic and 61 monozygotic adolescent twin pairs. Regression analysis demonstrated that lowbirth weight was associated with high levels of total cholesterol, low-density lipoprotein (LDL) cholesterol and apolipoprotein B (-0.17 mmol/liter per kg, P = 0.07; -0.:18 mmol/liter per kg, P = 0.04; and -0.07 g/liter per kg, P = 0.02, respectively) and with low levels of high-density lipoprotein(HDL) cholesterol (+0.04 mmol/liter per kg, P = 0.1), after adjustment forage, sex, and body mass index. Intrapair differences in birth weight were significantly associated with differences in total cholesterol, LDL cholesterol, and apolipoprotein B in dizygotic twins after adjustment for differences in current body mass index (-0.49 mmol/liter per kg, P = 0.02; -0.51 mmol/liter per kg, P = 0.01; and -0.10 g/liter per kg, P = 0.04, respectively), demonstrating that the larger the difference in birth weight, the higherthese risk factors in the twin with the lower birth weight, compared with the cotwin with the higher birth weight. In monozygotic twins, however, theassociations between intrapair differences in birth weight and differencesin total cholesterol, LDL cholesterol, and apolipoprotein B were in the opposite direction (+0.32 mmol/liter per kg, P = 0.03; +0.23 mmol/liter per kg, P = 0.08; and +0.06 g/liter per kg, P = 0.04, respectively). The association between intrapair differences in birth weight and differences in HDL cholesterol was not significant in dizygotic twins (+0.04 mmol/liter per kg,P = 0.6) and of borderline significance in monozygotic twins (+0.11 mmol/liter per kg, P = 0.05). These data suggest that genetic factors account forthe association of low birth weight with high levels of total cholesterol,LDL cholesterol, and apolipoprotein B, whereas intrauterine factors possibly play a role in the association between birth weight and HDL cholesterol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:06:03