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Titolo:
Latent class analysis of ADHD and comorbid symptoms in a population sampleof adolescent female twins
Autore:
Neuman, RJ; Heath, A; Reich, W; Bucholz, KK; Madden, PAF; Sun, LW; Todd, RD; Hudziak, JJ;
Indirizzi:
Washington Univ, Sch Med, St Louis, MO 63130 USA Washington Univ St LouisMO USA 63130 iv, Sch Med, St Louis, MO 63130 USA Univ Vermont, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 iv Vermont, Burlington, VT 05405 USA
Titolo Testata:
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
fascicolo: 7, volume: 42, anno: 2001,
pagine: 933 - 942
SICI:
0021-9630(200110)42:7<933:LCAOAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DOPAMINE TRANSPORTER GENE; III REPEAT POLYMORPHISM; DSM-IV ADHD; RECEPTOR POLYMORPHISM; MOTHERS REPORTS; DRD4 GENE; ASSOCIATION; CHILDREN;
Keywords:
attention-deficit/hyperactivity disorder; latent class analysis; twin studies; heritability; comorbidity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Neuman, RJ Washington Univ, Med Ctr, Dept Psychiat, Box 8134,660 S Euclid,St Louis, MO 63110 USA Washington Univ Box 8134,660 S Euclid St Louis MO USA 63110 USA
Citazione:
R.J. Neuman et al., "Latent class analysis of ADHD and comorbid symptoms in a population sampleof adolescent female twins", J CHILD PSY, 42(7), 2001, pp. 933-942

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a phenotypically heterogeneous and highly heritable syndrome, which commonly co-occurs with other psychiatry disorders. To assess the role of genetic influences in ADHD, we used latent class analysis (LCA) to identify subtypes of ADHD taking into account its comorbidity with separation anxiety, oppositional defiant disorder (ODD), and three major depression symptoms. A structured interview was used to collect diagnostic data from a population sample of 2904 adolescent female twins and their parents. LCA was applied to ADHD, separation anxiety, ODD symptom profiles obtained from the twins' parents, and major depression symptom profiles obtained from the twins' self-report. Odds ratios were used to test for familiality of class membership by examining the effect ofzygosity on twin concordance within and between latent classes. Structuralequation modeling was used to compute heritabilities for latent class membership. LCA revealed three ADHD categories of clinical interest: an inattentive subtype without comorbidity, a second inattentive subtype with increased number of ODD symptoms, and a combined inattentive/hyperactive-impulsivetype with elevated levels of ODD, separation anxiety, and depressive symptoms. LCA also distinguished an ODD class and a separation anxiety class, each without increased levels of other comorbid symptoms; a second ODD class co-occurring with increased separation anxiety and depression symptoms; anda pure depression class. Odds ratios for MZ contrasted with DZ twin concordance for individual latent class membership ranged from 2.5 to 19.4. Overall, 66 % of MZ pairs, but only 36 % of DZ pairs, were assigned to the same latent class, consistent with a genetic hypothesis for latent class membership. Individual class membership was shown to have high heritability ranging from .34-.85. The pattern of latent classes suggested that in the generalfemale adolescent population, there are three highly heritable ADHD subtypes, two of which are comorbid with other disorders. These classes were consistent with a genetic hypothesis for ADHD, with each class potentially reflecting a unique genetic subtype.

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Documento generato il 09/04/20 alle ore 13:26:37