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Titolo:
Engagement of inducible nitric oxide synthase at the rostral ventrolateralmedulla during mevinphos intoxication in the rat
Autore:
Chang, AYW; Chan, JYH; Kao, FJ; Huang, CM; Chan, SHH;
Indirizzi:
Natl Sun Yat Sen Univ, Ctr Neurosci, Kaohsiung 80424, Taiwan Natl Sun Yat Sen Univ Kaohsiung Taiwan 80424 ci, Kaohsiung 80424, Taiwan Natl Sun Yat Sen Univ, Dept Sci Biol, Kaohsiung 80424, Taiwan Natl Sun YatSen Univ Kaohsiung Taiwan 80424 ol, Kaohsiung 80424, Taiwan Natl Sun Yat Sen Univ, Dept Phys, Kaohsiung 80424, Taiwan Natl Sun Yat SenUniv Kaohsiung Taiwan 80424 ys, Kaohsiung 80424, Taiwan Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung, Taiwan Kaohsiung Vet Gen Hosp Kaohsiung Taiwan d Educ & Res, Kaohsiung, Taiwan Chang Gung Univ, Neurosci Grp, Kaohsiung, Taiwan Chang Gung Univ Kaohsiung Taiwan Univ, Neurosci Grp, Kaohsiung, Taiwan Chang Gung Mem Hosp, Kaohsiung, Taiwan Chang Gung Mem Hosp Kaohsiung Taiwan g Gung Mem Hosp, Kaohsiung, Taiwan
Titolo Testata:
JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 6, volume: 8, anno: 2001,
pagine: 475 - 483
SICI:
1021-7770(200111/12)8:6<475:EOINOS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC ARTERIAL-PRESSURE; HEART-RATE SIGNALS; MUSCARINIC RECEPTORS; SPECTRAL-ANALYSIS; BLOOD-PRESSURE; CHOLINERGIC MECHANISMS; AREA; MODULATION; NEURONS; AMINOGUANIDINE;
Keywords:
mevinphos intoxication; inducible nitric oxide synthase; M2 muscarinic receptor; rostral ventrolateral medulla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, AYW Natl Sun Yat Sen Univ, Ctr Neurosci, Kaohsiung 80424, Taiwan Natl Sun Yat Sen Univ Kaohsiung Taiwan 80424 ng 80424, Taiwan
Citazione:
A.Y.W. Chang et al., "Engagement of inducible nitric oxide synthase at the rostral ventrolateralmedulla during mevinphos intoxication in the rat", J BIOMED SC, 8(6), 2001, pp. 475-483

Abstract

We evaluated the relationship between the toxicity induced by the organophosphate mevinphos (Mev) and inducible nitric oxide synthase (iNOS) in the rostral ventrolateral medulla (RVLM), the medullary origin of sympathetic neurogenic vasomotor tone. Adult Sprague-Dawley rats that were anesthetized and maintained with propofol were used. Laser scanning confocal microscopic analysis revealed colocalization of the M2 subtype of muscarinic receptors (M2R) and iNOS immunoreactivity in RVLM neurons. Comicroinjection bilaterally of Mev (10 nmol) and artificial cerebrospinal fluid (aCSF) into the RVLMelicited a progressive decline in systemic arterial pressure (SAP) and heart rate. This was accompanied during phase 1 Mev intoxication by an increase in the power density of the very high-frequency (VHF; 5-9 Hz), high-frequency (HF; 0.8-2.4 Hz), low-frequency (LF; 0.25-0.8 Hz) and very low-frequency (VLF; 0-0.25 Hz) components of SAP signals. Phase 2 exhibited a reversalof the VHF and VLF power to control levels and a further reduction in the power density of both HF and LF components to below baseline. Hypotension and bradycardia promoted by Mev were significantly blunted on coadministration into the RVLM of the selective iNOS inhibitors S-methylisothiourea (250 pmol) or aminoguanidine (250 pmol). Not only was the augmented power density of HF and LF components during phase 1 Mev intoxication further enhanced,the reduced power of these two spectral components during phase 2 was appreciably antagonized. On the other hand, the temporal changes in VHF and VLFpower were essentially, the same as with coadministration of Mev and aCSF. We conclude that, as a cholinesterase inhibitor, Mev may induce toxicity via nitric oxide produced by iNOS on activation of the M2R by the accumulated acetylcholine in the RVLM. Copyright (C) 2001 National Science Council, ROC and S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:55:28