Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of single or repeated dermal exposure to methyl parathion on behavior and blood cholinesterase activity in rats
Autore:
Zhu, H; Rockhold, RW; Baker, RC; Kramer, RE; Ho, IK;
Indirizzi:
Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USAUniv Mississippi Jackson MS USA 39216 ol & Toxicol, Jackson, MS 39216 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 6, volume: 8, anno: 2001,
pagine: 467 - 474
SICI:
1021-7770(200111/12)8:6<467:EOSORD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASTICITY; CORTEX; PARKINSONISM; PESTICIDES; DEPLETION; TACRINE; ANIMALS; BRAIN;
Keywords:
methyl parathion; acetylcholinesterase; dermal exposure; learning; memory; motor function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Ho, IK Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 xicol, Jackson, MS 39216 USA
Citazione:
H. Zhu et al., "Effects of single or repeated dermal exposure to methyl parathion on behavior and blood cholinesterase activity in rats", J BIOMED SC, 8(6), 2001, pp. 467-474

Abstract

The effects of a single or repeated dermal administration of methyl parathion on motor function, learning and memory were investigated in adult female rats and correlated with blood cholinesterase activity. Exposure to a single dose of 50 mg/kg methyl parathion (75% of the dermal LD50) resulted in an 88% inhibition of blood cholinesterase activity and was associated with severe acute toxicity. Spontaneous locomotor activity and neuromuscular coordination were also depressed. Rats treated with a lower dose of methyl parathion, Le. 6.25 or 12.5 mg/kg, displayed minimal signs of acute toxicity. Blood cholinesterase activity and motor function, however, were depressed initially but recovered fully within 1-3 weeks. There were no delayed effects of a single dose of methyl parathion on learning acquisition or memory asassessed by a step-down inhibitory avoidance learning task. Repeated treatment with 1 mg/kg/day methyl parathion resulted in a 50% inhibition of blood cholinesterase activity. A decrease in locomotor activity and impairment of memory were also observed after 28 days of repeated treatment. Thus, a single dermal exposure of rats to doses of methyl parathion which are lower than those that elicit acute toxicity can cause decrements in both cholinesterase activity and motor function which are reversible. In contrast, repeated low-dose dermal treatment results in a sustained inhibition of cholinesterase activity and impairment of both motor function and memory. Copyright(C) 2001 National Science Council, ROC and S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:11:57