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Titolo:
The effect of alendronate (Fosamax (TM)) and implant surface on bone integration and remodeling in a canine model
Autore:
Frenkel, SR; Jaffe, WL; Della Valle, G; Jazrawi, L; Maurer, S; Baitner, A; Wright, K; Sala, D; Hawkins, M; Di Cesare, PE;
Indirizzi:
NYU, Hosp Joint Dis, Musculoskeletal Res Ctr, New York, NY 10003 USA NYU New York NY USA 10003 Musculoskeletal Res Ctr, New York, NY 10003 USA NYU, Hosp Joint Dis, Dept Orthopaed Surg, New York, NY 10003 USA NYU New York NY USA 10003 is, Dept Orthopaed Surg, New York, NY 10003 USA Stryker Howmedica Osteon Corp, Rutherford, NJ USA Stryker Howmedica OsteonCorp Rutherford NJ USA Corp, Rutherford, NJ USA
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 6, volume: 58, anno: 2001,
pagine: 645 - 650
SICI:
0021-9304(200112)58:6<645:TEOA((>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYAPATITE-COATED IMPLANTS; BIOLOGICAL RESPONSE; INTRAMEDULLARY BONE; TITANIUM; INGROWTH; COATINGS; OSSEOINTEGRATION; BISPHOSPHONATES; OSTEOPOROSIS; INTERFACE;
Keywords:
alendronate; implant interface; bone growth; mechanical testing; canine model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Frenkel, SR NYU, Hosp Joint Dis, Musculoskeletal Res Ctr, 301 E 17 St, NewYork, NY 10003 USA NYU 301 E 17 St New York NY USA 10003 , New York, NY 10003 USA
Citazione:
S.R. Frenkel et al., "The effect of alendronate (Fosamax (TM)) and implant surface on bone integration and remodeling in a canine model", J BIOMED MR, 58(6), 2001, pp. 645-650

Abstract

Patients at high risk for osteoporosis and its associated morbidity, including postmenopausal women, are being pharmacologically managed to stabilizeand improve bone mass. Alendronate sodium (Fosamax (TM)) is a commonly used antiresorptive agent effective in osteopenic women for reducing bone resorption, increasing bone density, and decreasing fracture incidence. With the increased incidence of alendronate-treated women who are undergoing hip replacement or fracture repair by prosthesis placement, data are needed to predict how alendronate affects host bone integration with uncemented surfaces. The aim of this study was to determine the effect of alendronate on newbone formation and attachment to implant surfaces in a normal and simulated estrogen-deficient, calcium-deficient canine model, using an implantable bone growth chamber. Alendronate did not affect host bone Integration to surfaces commonly used in uncemented total joint arthroplasty, but there weresignificant differences dependent solely on the type of surface. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:11:27