Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Biocompatible microcapsules with enhanced mechanical strength
Autore:
Chang, SJ; Lee, CH; Hsu, CY; Wang, YJ;
Indirizzi:
Natl Yang Ming Univ, Inst Biomed Engn, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 st Biomed Engn, Taipei 112, Taiwan Taipei Vet Gen Hosp, Shih Pai, Peitou, Taiwan Taipei Vet Gen Hosp Shih Pai Peitou Taiwan osp, Shih Pai, Peitou, Taiwan
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 1, volume: 59, anno: 2002,
pagine: 118 - 126
SICI:
0021-9304(200201)59:1<118:BMWEMS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALGINATE MICROCAPSULES; BIOMEDICAL APPLICATIONS; POLY(ETHYLENE GLYCOL); MICROENCAPSULATION; SURFACE; MEMBRANES; TRANSPLANTATION; POLY(L-LYSINE); ENCAPSULATION; GENERATION;
Keywords:
microcapsules; polyethylene glycol (PEG); alginate; block copolymer; biocompatibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, YJ Natl Yang Ming Univ, Inst Biomed Engn, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Engn, Taipei 112, Taiwan
Citazione:
S.J. Chang et al., "Biocompatible microcapsules with enhanced mechanical strength", J BIOMED MR, 59(1), 2002, pp. 118-126

Abstract

A block copolymer, (short-chain alginate)-co-MPEG, was synthesized and used for coating the capsular membranes of the photosensitive microcapsules. The resulted microcapsules exhibited an excellent mechanical strength. The permeability test results revealed that the capsular membrane was freely permeable to cytochrome C and myoglobin, less permeable to serum albumin, and almost impermeable to IgG. In the cell attachment test, the results showed that the surface formed by (short-chain alginate)-co-MPEG copolymer could effectively reduce cell adhesion as compared to poly(L-lysine) and alginate. The microcapsules were evaluated by intraperitoneal implantation experiment of mice. The results demonstrated that microcapsules coated with (short-chain alginate)-co-MPEG were more biocompatible than the conventional alginate/PLL/alginate microcapsules. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:04:03