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Titolo:
Implanted octacalcium phosphate is more resorbable than beta-tricalcium phosphate and hydroxyapatite
Autore:
Kamakura, S; Sasano, Y; Shimizu, T; Hatori, K; Suzuki, O; Kagayama, M; Motegi, K;
Indirizzi:
Tohoku Univ, Grad Sch Dent, Div Stomatol & Maxillofacial Surg, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 rg, Sendai, Miyagi 9808575, Japan Tohoku Univ, Grad Sch Dent, Div Oral Mol Biol, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 l Mol Biol, Sendai, Miyagi 980, Japan Tohoku Univ, Grad Sch Dent, Div Periodont & Endodont, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 & Endodont, Sendai, Miyagi 980, Japan Tohoku Univ, Grad Sch Dent, Div Stomatognath Physiol & Prosthodont, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 rosthodont, Sendai, Miyagi 980, Japan JGC Corp, Ctr Res & Dev, Oarai, Ibaraki, Japan JGC Corp Oarai Ibaraki Japan Corp, Ctr Res & Dev, Oarai, Ibaraki, Japan
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 1, volume: 59, anno: 2002,
pagine: 29 - 34
SICI:
0021-9304(200201)59:1<29:IOPIMR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBPERIOSTEAL IMPLANTATION; BONE SUBSTITUTES; OCP; RAT; HYDROXYLAPATITE; RECONSTRUCTION; OSTEOGENESIS; HYDROLYSIS;
Keywords:
octacalcium phosphate; beta-tricalcium phosphate; hydroxyapatite; bone repair; bone defect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kamakura, S Tohoku Univ, Grad Sch Dent, Div Stomatol & Maxillofacial Surg,Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Miyagi 9808575, Japan
Citazione:
S. Kamakura et al., "Implanted octacalcium phosphate is more resorbable than beta-tricalcium phosphate and hydroxyapatite", J BIOMED MR, 59(1), 2002, pp. 29-34

Abstract

Our previous studies have suggested that synthetic octacalcium phosphate (OCP) could be resorbed and replaced by newly formed bone if implanted in rat skull defects. We hypothesized that the implanted OCP is more resorbable than other commonly used bone graft substitutes of calcium phosphate compounds, such as hydroxyapatite (HA) and beta -tricalcium phosphate (beta -TCP). To test the hypothesis, the present study was designed to compare histomorphometrically resorption of the implanted OCP, HA, and beta -TCP, which were kept in the experimental cranial defect of rats for a long term. A full thickness of standardized trephine defect was made in the rat parietal bone, and the same volume of granules of OCP, HA, and beta -TCP were implanted into the defect. Five specimens of each group were fixed 6 months after implantation. The percentage of remaining implants (r-Imp%) and newly formed bone (n-Bone%) in the defect was analyzed histomorphometrically. The statistical analysis showed that the r-Imp% of OCP was significantly lower than that of HA and beta -TCP. In contrast, the n-Bone% of OCP was significantly higher than that of HA and beta -TCP. The present study has shown that the implanted OCP in the rat cranial defect is more resorbable than the implanted beta -TCP and HA, whereas the implanted OCP enhances bone formation more than the implanted beta -TCP and HA. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:38:18