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Titolo:
A custom three-dimensional electron bolus technique for optimization of postmastectomy irradiation
Autore:
Perkins, GH; McNeese, MD; Antolak, JA; Buchholz, TA; Strom, EA; Hogstrom, KR;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USAUniv Texas Houston TX USA 77030 Dept Radiat Oncol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Expt Radiat Oncol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 , Dept Radiat Phys, Houston, TX 77030 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 4, volume: 51, anno: 2001,
pagine: 1142 - 1151
SICI:
0360-3016(20011115)51:4<1142:ACTEBT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; RADIOTHERAPY; THERAPY;
Keywords:
postmastectomy irradiation; conformal electron therapy; electron bolus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: McNeese, MD Univ Texas, MD Anderson Canc Ctr, Dept Radiat Oncol, 1515 Holcombe Blvd,Box 97, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 97 Houston TX USA 77030 USA
Citazione:
G.H. Perkins et al., "A custom three-dimensional electron bolus technique for optimization of postmastectomy irradiation", INT J RAD O, 51(4), 2001, pp. 1142-1151

Abstract

Purpose: Postmastectomy irradiation (PMI) is a technically complex treatment requiring consideration of the primary tumor location, possible risk of internal mammary node involvement, varying chest wall thicknesses secondaryto surgical defects or body habitus, and risk of damaging normal underlying structures. In this report, we describe the application of a customized three-dimensional (3D) electron bolus technique for delivering PMI. Methods and Materials: A customized electron bolus was designed using a 3Dplanning system. Computed tomography (CT) images of each patient were obtained in treatment position and the volume to be treated was identified. Thedistal surface of the wax bolus matched the skin surface, and the proximalsurface was designed to conform to the 90% isodose surface to the distal surface of the planning target volume (PTV). Dose was calculated with a pencil-beam algorithm correcting for patient heterogeneity. The bolus was then fabricated from modeling wax using a computer-controlled milling device. Toaid in quality assurance, CT images with the bolus in place were generatedand the dose distribution was computed using these images. Results: This technique optimized the dose distribution while minimizing irradiation of normal tissues. The use of a single anterior field eliminatedfield junction sites. Two patients who benefited from this option are described: one with altered chest wall geometry (congenital pectus excavatum), and one with recurrent disease in the medial chest wall and internal mammary chain (IMC) area. Conclusion: The use of custom 3D electron bolus for PMI is an effective method for optimizing dose delivery. The radiation dose distribution is highly conformal, dose heterogeneity is reduced compared to standard techniques in certain suboptimal settings, and excellent immediate outcome is obtained. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/02/20 alle ore 05:52:08