Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparision of four different dose specification methods for high-dose-rate intracavitary radiation for treatment of cervical cancer
Autore:
Mai, J; Erickson, B; Rownd, J; Gillin, M;
Indirizzi:
Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 Oncol, Milwaukee, WI 53226 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 4, volume: 51, anno: 2001,
pagine: 1131 - 1141
SICI:
0360-3016(20011115)51:4<1131:COFDDS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTERNAL-BEAM IRRADIATION; RATE BRACHYTHERAPY; UTERINE CERVIX; RECTAL COMPLICATION; MADISON SYSTEM; CARCINOMA; FRACTIONATION; THERAPY; EXPERIENCE;
Keywords:
cervix cancer; brachytherapy; dosimetry; high-dose rate (HDR);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Erickson, B Med Coll Wisconsin, Dept Radiat Oncol, 8701 Watertown Plank Rd, Milwaukee,WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
J. Mai et al., "Comparision of four different dose specification methods for high-dose-rate intracavitary radiation for treatment of cervical cancer", INT J RAD O, 51(4), 2001, pp. 1131-1141

Abstract

Purpose: To compare the dose delivered to target tissues and dose-limitingstructures as defined by specific dose points with high-dose-rate intracavitary brachytherapy using tandem and ring or tandem and ovoids applicators,and to provide a reasonable approach to dose optimization. Methods and Materials: Dosimetry was obtained using four different dose specifications: (1) 100% of the dose prescribed in a tapered fashion along the tandem and 140% at the ovoid/ring surface, (2) 100% of the dose prescribed along the tandem and 100% at the ovoid/ring surface, (3) 100% of the doseprescribed to point A without any additional applicator specification points, and (4) nonoptimized plan using relative dwell weighting to simulate classic Fletcher low-dose-rate (LDR) loading with the dose specified at pointA. Point doses were recorded at A, B, and T (cervical tumor point), ICRU rectum, and ovoid/ring surface. Results: For the tandem and ovoids applicators, significant differences were found among the four different dose specification methods for point T and vaginal mucosal doses. When the dose was optimized to point A alone, the ovoid dwell weights were reduced, resulting in higher point T doses and underdosing of the vaginal mucosa. Fixed weighting based on Fletcher LDR loading specifications resulted in higher vaginal mucosa doses. For the tandem and ring applicators, significant differences were observed for vaginal mucosal doses and the ICRU rectal dose. Optimization to point A alone resulted in widely varying dosimetric distributions and vaginal mucosa doses up to 632% of the prescription dose. With nonoptimized fixed weighting, the vaginal wall dose and ICRU rectal dose were increased. Conclusion: Prescribing to dose optimization points in a tapered fashion along the tandem and at the ovoid/ring surface results in a pear-shaped dosedistribution resembling classic LDR systems. The other dose specification methods may result in underdosing of important target tissues or overdosingof adjacent dose-limiting structures. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:39:08