Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
An application of the challenge assay in boat builders exposed to low levels of styrene - a feasibility study of a possible biomarker for acquired susceptibility
Autore:
Oberheitmann, B; Frentzel-Beyme, R; Hoffmann, W;
Indirizzi:
Univ Bremen, UFT, Ctr Environm Res & Environm Technol, Div Epidemiol, D-28334 Bremen, Germany Univ Bremen Bremen Germany D-28334 iv Epidemiol, D-28334 Bremen, Germany BIPSE, Bremen Inst Prevent Res Social Med & Epidemiol, D-28359 Bremen, Germany BIPSE Bremen Germany D-28359 al Med & Epidemiol, D-28359 Bremen, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
fascicolo: 1, volume: 204, anno: 2001,
pagine: 23 - 29
SICI:
1438-4639(200110)204:1<23:AAOTCA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; CHROMOSOME-ABERRATIONS; DNA-REPAIR; ALZHEIMERS-DISEASE; HUMAN-LYMPHOCYTES; CANCER RISK; WORKERS; MORTALITY; MARKERS; DAMAGE;
Keywords:
styrene exposure; DNA repair; challenge assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Oberheitmann, B Univ Bremen, UFT, Ctr Environm Res & Environm Technol, DivEpidemiol, D-28334 Bremen, Germany Univ Bremen Bremen Germany D-28334 28334 Bremen, Germany
Citazione:
B. Oberheitmann et al., "An application of the challenge assay in boat builders exposed to low levels of styrene - a feasibility study of a possible biomarker for acquired susceptibility", INT J HYG E, 204(1), 2001, pp. 23-29

Abstract

Sensitivity to carcinogens and susceptibility for malignant diseases may be related to genetic predisposition, e.g. polymorphisms in toxicant-metabolizing enzymes or DNA repair deficiencies. The latter may also be acquired by exposure to substances that interfere with DNA repair processes. Application of the challenge assay to an exposed population may allow scientists tostudy the interference of DNA repair as an acquired susceptibility phenomenon. The assay was therefore used in a feasibility study to evaluate its application. A group of 14 workers exposed to low levels of styrene (mean < 100 mg/m(3) styrene in air; 35 mug/l styrene in blood) and a reference of seven controls were investigated for structural chromosomal aberrations usingFISH. The rate of exchange-type aberrations per 100 metaphases was 0.14 (95% CI, 0.05-0.31) in controls and 0.22 (95% CI, 0.13-0.36) in exposed workers. The difference is not statistically significant. Interaction with DNA repair was measured in the 14 workers and 2 historical controls using the challenge assay Exchange-type aberrations per 100 metaphases after X-ray challenge of 1.66 Gy were 13.26 (10.53-16.50) and 16.19 (15.00-171.40) for the controls and exposed, respectively. The difference is statistically significant (p < 0.038). Among the exposed group, the challenge response was also significantly correlated with the cumulative lifetime exposure to styrene (R-2 = 0.3996; p < 0.015) but not with the current exposure as measured in blood (R-2 = 0.0226; p = 0.700). The challenge responses in the short-term and long-term exposed subgroups were 15.55 (14.23-16.96) and 17.90 (15.64-20.39), respectively, based on sample sizes of 5 and 9, respectively. The difference was not significant. Hence, data from our study are consistent withthe hypothesis that long-term exposure to styrene can interfere with DNA repair activities. The lack of statistically significant differences in someof the data may be due to the small sample size and a possible confoundingby age in our investigation. Additional data from our ongoing study shouldclarify this uncertainty.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:12:29