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Titolo:
A clinicopathological study of 20 patients with T/natural killer (NK)-celllymphoma-associated hemophagocytic syndrome with special reference to nasal and nasal-type NK/T-cell lymphoma
Autore:
Takahashi, N; Miura, I; Chubachi, A; Miura, AB; Nakamura, S;
Indirizzi:
Akita Univ, Sch Med, Dept Internal Med 3, Akita 0108543, Japan Akita UnivAkita Japan 0108543 Dept Internal Med 3, Akita 0108543, Japan Kotoh Gen Hosp, Dept Internal Med, Akita, Japan Kotoh Gen Hosp Akita Japan oh Gen Hosp, Dept Internal Med, Akita, Japan Aichi Canc Ctr Hosp, Dept Pathol & Genet, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 enet, Nagoya, Aichi 464, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 3, volume: 74, anno: 2001,
pagine: 303 - 308
SICI:
0925-5710(200110)74:3<303:ACSO2P>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-LYMPHOMA; SPECTRUM; FEATURES;
Keywords:
lymphoma-associated hemophagocytic syndrome; nasal and nasal-type NK/T-cell lymphoma; Epstein-Barr virus; CD56; cytotoxic molecules;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, N Akita Univ, Sch Med, Dept Internal Med 3, Hondo 1-1-1, Akita 0108543, Japan Akita Univ Hondo 1-1-1 Akita Japan 0108543 ta 0108543, Japan
Citazione:
N. Takahashi et al., "A clinicopathological study of 20 patients with T/natural killer (NK)-celllymphoma-associated hemophagocytic syndrome with special reference to nasal and nasal-type NK/T-cell lymphoma", INT J HEMAT, 74(3), 2001, pp. 303-308

Abstract

We describe the clinicopathological features of 20 patients with T/naturalkiller (NK)-cell lymphoma-associated hemophagocytic syndrome (T/NK-LAHS). These patients were categorized into 2 groups according to the onset of hemophagocytic syndrome (HPS). Group 1 developed HPS during the clinical course, typically at the terminal phase of the disease. This group consisted of 7 patients with extranodal lymphoma arising in the nasal cavity, paranasal cavity, tonsils, or skin at presentation. In 5 of these patients, the preferred diagnosis was nasal and nasal-type NK/T-cell lymphoma. whereas the disease diagnoses in the remaining 2 patients were peripheral T-cell lymphoma of unspecified type and angioimmunoblastic T-cell lymphoma, respectively. Group 2 consisted of 13 patients whose disease corresponded to so-called malignant histiocytosis-like lymphoma, which is characterized by HPS at the initial presentation and the infiltration of the liver, spleen, and/or bone marrow without tumor formation. Nine of these 13 cases were found to have common histopathological features: CD56(+), Epstein-Barr virus positivity, cytotoxic molecules, and nasal-type NK/T-cell lymphoma. The very poor prognosis of T/NK-LAHS may be partly explained by the finding that nasal and nasal-type NK/T-cell lymphoma, which is resistant to standard chemotherapy, madeup the highest percentage (70%) of the cases. (C) 2001 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 11:51:57