Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Influence of the angiotensin II receptor antagonist losartan on diuretic-induced metabolic effects in elderly hypertensive patients: comparison with a calcium channel blocker
Autore:
Ohnishi, K; Kohno, M; Yukiiri, K; Masugata, H; Wada, Y; Takagi, Y; Ohmori, K;
Indirizzi:
Kagawa Med Univ, Sch Med, Dept Internal Med 2, Kagawa 7610793, Japan Kagawa Med Univ Kagawa Japan 7610793 ternal Med 2, Kagawa 7610793, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
fascicolo: 10, volume: 39, anno: 2001,
pagine: 417 - 422
SICI:
0946-1965(200110)39:10<417:IOTAIR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITOR; BRAIN NATRIURETIC PEPTIDE; SERUM URIC-ACID; HYDROCHLOROTHIAZIDE; THERAPY; MILD;
Keywords:
angiotensin II receptor antagonist; diuretics; uric acid; potassium; elderly hypertensive patients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Kohno, M Kagawa Med Univ, Sch Med, Dept Internal Med 2, 1750-1 Ikenobe, Kagawa 7610793, Japan Kagawa Med Univ 1750-1 Ikenobe Kagawa Japan 7610793 10793, Japan
Citazione:
K. Ohnishi et al., "Influence of the angiotensin II receptor antagonist losartan on diuretic-induced metabolic effects in elderly hypertensive patients: comparison with a calcium channel blocker", INT J CL PH, 39(10), 2001, pp. 417-422

Abstract

Objective: Diuretic therapy frequently induces Undesirable biochemical changes and side effects. We compared metabolic effects of a low-dose diuretic(D) given in combination with an angiotensin II receptor antagonist, losartan (L), with those resulting from a diuretic given in combination with a calcium channel blocker, slow-release nifedipine (N). Material and methods: Thirty-seven elderly patients with mild to moderate hypertension (mean age.71 +/- 3 years) were treated with either L+D (n = 18) or N+D (n = 19) for 1 year. Diuretic therapy included low-dose trichlormethiazide or low-dose furosemide in numbers of patients that were similar between L+D and N+D groups. Blood pressure, serum electrolytes, uric acid, blood glucose, renal function and lipid parameters were measured at baseline, 6 months and 1 year. Results: Effective blood pressure control was observed in both groups at 6 months, and with further improvement at 1 year, Serum potassium was significantly decreased from baseline at 6 months (p < 0.01) and 1 year (p < 0.01)in the N+D group, but not in the L+D group. Serum uric acid was significantly increased from baseline at 6 months (p < 0.01) and 1 year (p < 0.01) inthe N+D group, but had minimally decreased at 1 year in the L+D group (p <0.1). Blood glucose, renal function and lipid parameters did not change ineither group. Conclusion: The combination of losartan and low-dose diuretics effectively treated hypertension in elderly Patients while minimizing the metabolic consequences of diuretic therapy. Larger trials will be necessary to confirm this finding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:45:05