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Titolo:
Flutamide-induced acute hepatitis in advanced prostate cancer patients
Autore:
Kraus, I; Vitezic, D; Oguic, R;
Indirizzi:
Univ Hosp Ctr, Dept Sci & Clin Pharmacol, Rijeka, Croatia Univ Hosp Ctr Rijeka Croatia Dept Sci & Clin Pharmacol, Rijeka, Croatia Univ Rijeka, Sch Med, Dept Pharmacol, CRO-51000 Rijeka, Croatia Univ Rijeka Rijeka Croatia CRO-51000 harmacol, CRO-51000 Rijeka, Croatia Univ Hosp Ctr, Dept Gastroenterol, Rijeka, Croatia Univ Hosp Ctr Rijeka Croatia p Ctr, Dept Gastroenterol, Rijeka, Croatia Univ Hosp Ctr, Dept Urol, Rijeka, Croatia Univ Hosp Ctr Rijeka CroatiaUniv Hosp Ctr, Dept Urol, Rijeka, Croatia
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
fascicolo: 9, volume: 39, anno: 2001,
pagine: 395 - 399
SICI:
0946-1965(200109)39:9<395:FAHIAP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIANDROGEN FLUTAMIDE; LIVER TOXICITY; HEPATOTOXICITY; CARCINOMA; FAILURE; THERAPY; RAT;
Keywords:
acute hepatitis; flutamide; adverse effects; prostate cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Vitezic, D Univ Hosp Ctr, Dept Sci & Clin Pharmacol, Rijeka, Croatia Univ Hosp Ctr Rijeka Croatia Clin Pharmacol, Rijeka, Croatia
Citazione:
I. Kraus et al., "Flutamide-induced acute hepatitis in advanced prostate cancer patients", INT J CL PH, 39(9), 2001, pp. 395-399

Abstract

Objective: To describe the characteristics of 3 patients hospitalized in the Department of Gastroenterology, University Hospital Center, Rijeka, as the result of acute hepatitis, a rare adverse drug reaction to flutamide. Patients and results: All 3 patients with advanced prostate carcinoma were treated with oral flutamide at a dose rate of 250 mg 3 times daily. The patients developed clinical signs (jaundice, anorexia, nausea, dark urine etc.) and laboratory liver function test changes (high aminotransferase and bilirubin level), indicative of acute hepatitis, 20 - 22 weeks after commencing flutamide treatment. The flutamide therapy was immediately discontinued andthis resulted in spontaneous remission (clinical and liver function test results returned to normal) during the next 8 weeks. Conclusion: Our data clearly suggest that flutamide causes acute hepatitis and that the monitoringof the patients' liver function tests in order to detect these changes as early as possible, is important.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:27:08