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Titolo:
Primary resistance to clarithromycin in clinical strains of Helicobacter pylori isolated from children in Poland
Autore:
Dzierzanowska-Fangrat, K; Rozynek, E; Jozwiak, P; Celinska-Cedro, D; Madalinski, K; Dzierzanowska, D;
Indirizzi:
Childrens Mem Hlth Inst, Dept Clin Immunol, PL-04736 Warsaw, Poland Childrens Mem Hlth Inst Warsaw Poland PL-04736 , PL-04736 Warsaw, Poland Childrens Mem Hlth Inst, Dept Clin Microbiol, PL-04736 Warsaw, Poland Childrens Mem Hlth Inst Warsaw Poland PL-04736 , PL-04736 Warsaw, Poland Childrens Mem Hlth Inst, Dept Gastroenterol & Nutr, PL-04736 Warsaw, Poland Childrens Mem Hlth Inst Warsaw Poland PL-04736 , PL-04736 Warsaw, Poland
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 4, volume: 18, anno: 2001,
pagine: 387 - 390
SICI:
0924-8579(2001)18:4<387:PRTCIC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
23S RIBOSOMAL-RNA; POINT MUTATIONS; GENE; METRONIDAZOLE;
Keywords:
Helicobacter pylori; clarithromycin; resistance; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Dzierzanowska-Fangrat, K Childrens Mem Hlth Inst, Dept Clin Immunol, AlejaDzieci Polskich 20, PL-04736 Warsaw, Poland Childrens Mem Hlth Inst Aleja Dzieci Polskich 20 Warsaw Poland PL-04736
Citazione:
K. Dzierzanowska-Fangrat et al., "Primary resistance to clarithromycin in clinical strains of Helicobacter pylori isolated from children in Poland", INT J ANT A, 18(4), 2001, pp. 387-390

Abstract

Helicobacter pylori resistance to clarithromycin is an important factor inthe failure of eradication therapy. The resistance results from point mutations in the 23S rRNA gene of H. pylori. The prevalence of primary resistance of H. pylori to clarithromycin in children and mutations associated withresistance were studied and it was found that 23.5% (23/98) of H. pylori strains isolated in our hospital during 1998-2000 were resistant to clarithromycin. The primary resistance was mainly caused by an A2143G mutation, butthe isolates with an A2142G mutation had higher MICs for clarithromycin compared with those with an A2143G mutation: median MIC 256 versus 16 mg/l. Comparison of our data with previous results showed that the prevalence of H. pylori resistance to clarithromycin in children has increased in Poland over the last three years, however the difference was not significant (23.5 vs. 17%, P = 0.22). (C) 2001 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 17:56:02