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Titolo:
Influenza A antigen exposure selects dominant V(beta)17(+) TCR in human CD8(+) cytotoxic T cell responses
Autore:
Lawson, TM; Man, S; Williams, S; Boon, ACM; Zambon, M; Borysiewicz, LK;
Indirizzi:
Univ Wales Coll Med, Dept Med, Cardiff CF14 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF14 4XN CF14 4XN, S Glam, Wales Cent Publ Hlth Lab, Enter & Resp Virus Lab, London NW9 5HT, England Cent Publ Hlth Lab London England NW9 5HT s Lab, London NW9 5HT, England
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 11, volume: 13, anno: 2001,
pagine: 1373 - 1381
SICI:
0953-8178(200111)13:11<1373:IAAESD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; DENDRITIC CELLS; LYMPHOCYTES-T; RECEPTOR; PEPTIDE; VIRUS; BETA; REPERTOIRE; INFECTION; RECOGNITION;
Keywords:
affinity; cytotoxic T cell; human; influenza A; TCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Lawson, TM Univ Wales Coll Med, Dept Med, Heath Pk, Cardiff CF14 4XN, S Glam, Wales Univ Wales Coll Med Heath Pk Cardiff S Glam Wales CF14 4XN ales
Citazione:
T.M. Lawson et al., "Influenza A antigen exposure selects dominant V(beta)17(+) TCR in human CD8(+) cytotoxic T cell responses", INT IMMUNOL, 13(11), 2001, pp. 1373-1381

Abstract

During acute human viral infections, such as influenza A, specific cytotoxic T lymphocytes (CTL) are generated which aid virus clearance. We have observed that in HLA-A*0201(+) subjects, CTL expressing V(beta)17(+) TCR and recognizing a peptide from the influenza A matrix protein (M1(58-66)) dominate this response. In experimental models of infection such dominance can bedue to inheritance of a restricted T cell repertoire or acquired consequent on expansion of CTL bearing an optimum TCR conformation against the MHC-peptide complex. To examine how influenza A infection might influence the development of TCR V(beta)17 expansion, we studied influenza A-specific CTL in a cross-sectional study of 82 HLA-A*0201(+) individuals from birth (cord blood) to adulthood. Primary M1(58-66)-specific CTL were detected in cord blood, but their TCR were diverse and depletion of V(beta)17(+) cells did not abrogate specific cytotoxicity. In contrast following natural influenza Ainfection, TCR V(beta)17(+) CTL dominated to the extent that only one of nine adult CTL lines retained any functional activity after in vitro depletion of V(beta)17(+) CTL. These results suggest that the dominance of V(beta)17(+) TCR among adult M1(58-66)-specific CTL results from maturation and focussing of the response driven by exposure to influenza, and have implications for optimum immunization strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:59:38