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Titolo:
Arterial wave reflections and survival in end-stage renal failure
Autore:
London, GM; Blacher, J; Pannier, B; Guerin, AP; Marchais, SJ; Safar, ME;
Indirizzi:
Hop FH Manhes, Serv Hemodialyse, F-91712 Fleury Merogis, St Genevieve De, France Hop FH Manhes Fleury Merogis St Genevieve De France F-91712 ve De, France Hop Broussais, Serv Med Interne, F-75674 Paris, France Hop Broussais Paris France F-75674 rv Med Interne, F-75674 Paris, France
Titolo Testata:
HYPERTENSION
fascicolo: 3, volume: 38, anno: 2001,
pagine: 434 - 438
SICI:
0194-911X(200109)38:3<434:AWRASI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR MORTALITY; DEPENDENT VASODILATATION; AORTIC COMPLIANCE; DIALYSIS PATIENTS; VASCULAR-DISEASE; PULSE PRESSURE; BLOOD-PRESSURE; HEMODIALYSIS; CIRCULATION; PREDICTOR;
Keywords:
end-stage renal failure; aortic stiffness; mortality; arterial wave reflection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: London, GM Hop FH Manhes, Serv Hemodialyse, 8 Grande Rue, F-91712 Fleury Merogis, St Genevieve De, France Hop FH Manhes 8 Grande Rue Fleury Merogis St Genevieve De France F-91712
Citazione:
G.M. London et al., "Arterial wave reflections and survival in end-stage renal failure", HYPERTENSIO, 38(3), 2001, pp. 434-438

Abstract

The increased effect of arterial wave reflections on central arteries likethe common carotid artery seen in end-stage renal failure (ESRF) patients favors myocardial hypertrophy and oxygen consumption and alters coronary blood flow distribution. Nevertheless, the impact of wave reflection on the outcome and end points such as mortality remains to be demonstrated. One hundred eighty ESRF patients (age, 54 +/- 16 years) were monitored for 52 +/- 36 months (mean +/- SD). Seventy deaths, including 40 cardiovascular (CV) and 30 non-CV events, occurred. At entry, patients, in addition to standard clinical and biochemical analyses, underwent aortic pulse wave velocity measurement and determination of arterial wave reflexion by applanation tonometry on the common carotid artery that was expressed as augmentation index. Cox analyses demonstrated that predictors of all-cause and CV mortality were age, aortic pulse wave velocity, low diastolic blood pressure, preexisting CV disease, and increased augmentation index, whereas the prescription ofan ACE inhibitor had a favorable effect on survival. After adjustment for all confounding factors, the risk ratio for each 10% increase in augmentation index was 1.51 (95% confidence interval, 1.23 to 1.86; P<0.0001) for all-cause mortality and 1.48 (95% confidence interval, 1.16 to 1.90; P<0.0001)for CV mortality. These results provide the first direct evidence that in ESRF patients increased effect of arterial wave reflections is an independent predictor of all-cause and CV mortality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:10:30