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Titolo:
Role of corticotrophin-releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure
Autore:
Correia, MLG; Morgan, DA; Mitchell, JL; Sivitz, WL; Mark, AL; Haynes, WG;
Indirizzi:
Univ Iowa, Coll Med, Dept Internal Med, Specialized Ctr Res Hypertens Genet, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Hypertens Genet, Iowa City, IA 52242 USA Vet Affairs Med Ctr, Iowa City, IA 52242 USA Vet Affairs Med Ctr Iowa City IA USA 52242 d Ctr, Iowa City, IA 52242 USA
Titolo Testata:
HYPERTENSION
fascicolo: 3, volume: 38, anno: 2001,
pagine: 384 - 388
SICI:
0194-911X(200109)38:3<384:ROCFIE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; OBESE GENE-PRODUCT; NEUROPEPTIDE-Y; OB/OB MICE; BLOOD-PRESSURE; RATS; HORMONE; HYPOTHALAMUS; TARGETS; SYSTEM;
Keywords:
arteries; blood pressure; leptin; sympathetic nervous system; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Haynes, WG Univ Iowa, Coll Med, Dept Internal Med, Specialized Ctr Res Hypertens Genet, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 enet, Iowa City, IA 52242 USA
Citazione:
M.L.G. Correia et al., "Role of corticotrophin-releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure", HYPERTENSIO, 38(3), 2001, pp. 384-388

Abstract

Leptin and corticotrophin-releasing factor increase sympathetic nervous activity to interscapular brown adipose tissue, kidneys, and adrenal glands. Leptin is known to increase hypothalamic corticotrophin-releasing factor. In this study, we tested the hypothesis that leptin-dependent increases in sympathetic nervous activity are mediated through increases in central nervous system corticotrophin-releasing factor activity. We examined the effectsof intracerebroventricular administration of corticotrophin-releasing factor and intravenous leptin on sympathetic nervous activity to interscapular brown adipose tissue through multifiber neurography in anesthetized Sprague-Dawley rats pretreated with intracerebroventricular alpha-helical corticotrophin-releasing factor(9-41) (corticotrophin-releasing factor receptor antagonist) or vehicle. Centrally administered corticotrophin-releasing factorsubstantially increased interscapular brown adipose tissue sympathetic nervous activity. The responses to corticotrophin-releasing factor were substantially attenuated in animals pretreated with alpha-helical corticotrophin-releasing factor(9-41). Leptin-dependent increases in interscapular brown adipose tissue sympathetic nervous activity were significantly inhibited by pretreatment with alpha-helical corticotrophin-releasing factor(9-41). Interestingly, leptin also significantly increased arterial pressure over 6 hours, but this pressor action was not attenuated by the corticotrophin-releasing factor receptor antagonist. These results suggest that corticotrophin-releasing factor may mediate the sympathoexcitatory effect of leptin on thermogenic tissue without altering its cardiovascular actions.

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Documento generato il 20/01/20 alle ore 22:51:26