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Titolo:
Conventional antihypertensive drug therapy does not prevent the increase of pulse pressure with age
Autore:
Mourad, JJ; Blacher, J; Blin, P; Warzocha, U;
Indirizzi:
St Michel Hosp, Dept Internal Med, F-75015 Paris, France St Michel Hosp Paris France F-75015 Internal Med, F-75015 Paris, France Hop Broussais, Dept Internal Med, Paris, France Hop Broussais Paris France Broussais, Dept Internal Med, Paris, France ICARE, Paris, France ICARE Paris FranceICARE, Paris, France
Titolo Testata:
HYPERTENSION
fascicolo: 4, volume: 38, anno: 2001,
pagine: 958 - 961
SICI:
0194-911X(200110)38:4<958:CADTDN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTOLIC BLOOD-PRESSURE; CORONARY HEART-DISEASE; CARDIOVASCULAR MORTALITY; RANDOMIZED TRIAL; HYPERTENSION; RISK;
Keywords:
hypertension, essential; antihypertensive therapy; blood pressure; pulse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mourad, JJ St Michel Hosp, Dept Internal Med, 33 Rue Olivier de Serres, F-75015 Paris, France St Michel Hosp 33 Rue Olivier de Serres Paris France F-75015 e
Citazione:
J.J. Mourad et al., "Conventional antihypertensive drug therapy does not prevent the increase of pulse pressure with age", HYPERTENSIO, 38(4), 2001, pp. 958-961

Abstract

Increased pulse pressure (PP), an independent predictor of cardiovascular risk, may be quantified on the basis of the prevalence of isolated systolichypertension (ISH) in the population at large. The purpose of this study was to estimate the prevalence of ISH and its relation to age and drug therapy in a large group of outpatient hypertensive subjects in France. Between March and December 1999, 2975 French general practitioners included 17 716 consecutive patients with uncontrolled hypertension (systolic blood pressure [SBP] > 140 mm Hg and/or diastolic blood pressure [DBP] >90 mm Hg), either treated or not treated. They were asked to complete a questionnaire concerning associated cardiovascular risk factors and ongoing antihypertensive therapy. Subjects were classified according to 5 age ranges (from 18 to 103 years). In each age range, SBP, DBP, mean blood pressure, and PP were significantly lower (P<0.001) in treated subjects than in untreated subjects, with the exception of PP in subjects >75 years. The latter finding resulted from a significant increase of SBP and PP with age, together with a significant lowering of DBP with age, irrespective of drug treatment. Subsequently,the prevalence of ISH increased with age from 20.4% to 35.2% in men and women. In any given age range, drug therapy for hypertension is associated with marginally lower values of PP. In the studied populations, the increase of PP with age is independent of gender and of the presence of antihypertensive drug treatment, leading to an increased prevalence of ISH and a subsequent increase of cardiovascular risk with age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:56:39