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Titolo:
Inverse association between free insulin-like growth factor-1 and isovolumic relaxation in arterial systemic hypertension
Autore:
Galderisi, M; Vitale, G; Lupoli, G; Barbieri, M; Varricchio, G; Carella, C; de Divitiis, O; Paolisso, G;
Indirizzi:
Univ Naples 2, Cattedra Geriatria, I-80138 Naples, Italy Univ Naples 2 Naples Italy I-80138 edra Geriatria, I-80138 Naples, Italy Univ Naples 2, Ist Endocrinol, I-80138 Naples, Italy Univ Naples 2 Naples Italy I-80138 Ist Endocrinol, I-80138 Naples, Italy Univ Naples Federico II, Ist Med & Clin Sperimentale, Cattedra Med Urgenza, Naples, Italy Univ Naples Federico II Naples Italy attedra Med Urgenza, Naples, Italy Univ Naples Federico II, Dipartimento Endocrinol & Oncol Mol & Clin, Naples, Italy Univ Naples Federico II Naples Italy & Oncol Mol & Clin, Naples, Italy
Titolo Testata:
HYPERTENSION
fascicolo: 4, volume: 38, anno: 2001,
pagine: 840 - 845
SICI:
0194-911X(200110)38:4<840:IABFIG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR DIASTOLIC FUNCTION; IGF(1) AUTOCRINE SYSTEM; FACTOR-I; ENHANCED EXPRESSION; CIRCULATING INSULIN; CARDIAC-HYPERTROPHY; NITRIC-OXIDE; HORMONE; HEART; RAT;
Keywords:
insulin growth factor; hypertension, arterial; echocardiography; diastole; relaxation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Paolisso, G Univ Naples 2, Cattedra Geriatria, Piazza Miraglia 2, I-80138 Naples, Italy Univ Naples 2 Piazza Miraglia 2 Naples Italy I-80138 s, Italy
Citazione:
M. Galderisi et al., "Inverse association between free insulin-like growth factor-1 and isovolumic relaxation in arterial systemic hypertension", HYPERTENSIO, 38(4), 2001, pp. 840-845

Abstract

Several trials have suggested that insulin-like growth factor-1 (IGF-1) may have a pathophysiological role in the development of arterial essential hypertension. To verify the possible association of IGF-1 with left ventricular morphological and functional echocardiographic parameters in hypertension, we studied 40 male patients with newly diagnosed hypertension and 15 normotensive control subjects. Doppler echocardiography was performed and circulating free IGF-1 levels were determined in all subjects. Circulating free IGF-1 levels were higher in hypertensives than in control subjects (P<0.01). A significant inverse correlation was observed between free IGF-1 and isovolumic relaxation time in the overall population (r= -0.37, P<0.01) and in hypertensives (r= -0.57, P<0.0001), whereas this relation disappears in normotensives. These results were confirmed by multivariate analysis. The present study confirms that arterial essential hypertension represents a clinical condition associated with an increased synthesis of IGF-1. The observation of an inverse, independent association between free IGF-1 and isovolumic relaxation time suggests 2 alternative hypotheses: a possible beneficial effect of IGF-1 to diastolic relaxation or a resistance to IGF-1 in hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:24:43