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Titolo:
Two linked blood pressure quantitative trait loci on chromosome 10 definedby Dahl rat congenic strains
Autore:
Garrett, MR; Zhang, XT; Dukhanina, OI; Deng, AY; Rapp, JP;
Indirizzi:
Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43614 USA Med Coll OhioToledo OH USA 43614 Physiol & Mol Med, Toledo, OH 43614 USA
Titolo Testata:
HYPERTENSION
fascicolo: 4, volume: 38, anno: 2001,
pagine: 779 - 785
SICI:
0194-911X(200110)38:4<779:TLBPQT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RAT; GENETIC-ANALYSIS; GENOME SCAN; LINKAGE; QTL; SUSCEPTIBILITY; SIBLINGS; MODEL;
Keywords:
sodium; genetics; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Rapp, JP Med Coll Ohio, Dept Physiol & Mol Med, 3035 Arlington Ave, Toledo, OH 43614 USA Med Coll Ohio 3035 Arlington Ave Toledo OH USA 43614 OH 43614 USA
Citazione:
M.R. Garrett et al., "Two linked blood pressure quantitative trait loci on chromosome 10 definedby Dahl rat congenic strains", HYPERTENSIO, 38(4), 2001, pp. 779-785

Abstract

A quantitative trait locus (QTL) for blood pressure was previously detected on rat chromosome 10 (RNO10) by linkage analysis and confirmed by the construction of congenic strains that encompass large regions of RNO10. In thepresent study, the rat RNO10 blood pressure QTL was dissected by the further construction of congenic substrains. The original congenic region was shown to contain 2 blood pressure QTLs (QTL 1 and QTL 2) approximate to 24 cMapart. These were localized to a <2.6-cM region between markers D10Rat27 and D10Rat24 for QTL 1 and to a < 3.2-cM region between D10Rat12 and D10Mco70 for QTL 2. Comparative mapping suggests that the rat RNO10 QTL 2 could belocalized very close to a blood pressure QTL described by sib-pair analysis on human chromosome 17, but this is not definitively established because of multiple and complex chromosomal rearrangements between rodents and humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:08:59