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Titolo:
Linkage of left ventricular contractility to chromosome 11 in humans - TheHyperGEN study
Autore:
Arnett, DK; Devereux, RB; Kitzman, D; Oberman, A; Hopkins, P; Atwood, L; Dewan, A; Rao, DC;
Indirizzi:
Univ Minnesota, Div Epidemiol, Minneapolis, MN 55454 USA Univ Minnesota Minneapolis MN USA 55454 demiol, Minneapolis, MN 55454 USA Cornell Univ, Coll Med, New York, NY USA Cornell Univ New York NY USACornell Univ, Coll Med, New York, NY USA Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Univ Alabama, Div Prevent Med, Birmingham, AL USA Univ Alabama BirminghamAL USA bama, Div Prevent Med, Birmingham, AL USA Univ Utah, Salt Lake City, UT USA Univ Utah Salt Lake City UT USAUniv Utah, Salt Lake City, UT USA Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA
Titolo Testata:
HYPERTENSION
fascicolo: 4, volume: 38, anno: 2001,
pagine: 767 - 772
SICI:
0194-911X(200110)38:4<767:LOLVCT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; BINDING-PROTEIN-C; PRESSURE-OVERLOAD HYPERTROPHY; ARTERIAL-HYPERTENSION; CARDIOVASCULAR RISK; CARDIAC-HYPERTROPHY; MUTATIONS; GENE; ECHOCARDIOGRAPHY; MECHANICS;
Keywords:
genes; gene expression; myocardium; hypertension, genetic; race;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Arnett, DK Univ Minnesota, Div Epidemiol, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA Univ Minnesota 1300 S 2nd St,Suite 300 Minneapolis MN USA 55454
Citazione:
D.K. Arnett et al., "Linkage of left ventricular contractility to chromosome 11 in humans - TheHyperGEN study", HYPERTENSIO, 38(4), 2001, pp. 767-772

Abstract

Impaired left ventricular (LV) contractility is a major cause of cardiovascular death, especially congestive heart failure. The identification of susceptibility genes that contribute to impaired LV contractility may uncover mechanisms underlying LV contractile impairment and the development of congestive heart failure. The Hypertension Genetic Epidemiology Network (HyperGEN) collected echocardiographic measurements of myocardial contractility ina large biethnic sample of hypertensive siblings (390 blacks and 398 whites in 179 and 165 sibships, respectively). All participants expressed hypertension before age 60 years, and the mean age of siblings was 52 years in blacks and 61 years in whites. We adjusted myocardial contractility for gender, age, and age(2), and we calculated standardized residuals separately formen and women in both ethnic groups. We conducted multipoint variance components linkage analysis using GENEHUNTER2 and 387 anonymous markers (CHCL8 marker set). We found evidence for significant linkage to a microsatellite marker, D11S1993 (lod, 3.93 in blacks), approximate to 54 cM from the tip of the short arm of chromosome 11, that accounted for 72% of the phenotypic variation in LV contractility. A chromosome 22 locus showed suggestive evidence for linkage (lod, 2.83 in whites and 1.15 in blacks). The chromosome 11 peak coincides with the region containing myosin-binding protein C. Mutations in this gene are linked to familial hypertrophic cardiomyopathy. Our results show strong evidence for linkage of a region of chromosome 11 with LV contractility in blacks and suggest that an important gene for impaired LV contractility is harbored in this region.

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Documento generato il 24/11/20 alle ore 13:50:09