Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effects of radiotherapy and chemotherapy on female reproduction
Autore:
Meirow, D; Nugent, D;
Indirizzi:
Rabin Med Ctr, Dept Obstet & Gynecol, Tel Aviv, Israel Rabin Med Ctr Tel Aviv Israel , Dept Obstet & Gynecol, Tel Aviv, Israel Univ Leeds, Gen Infirm Leeds, Ctr Reprod Growth & Dev, Leeds LS2 9NS, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9NS S2 9NS, W Yorkshire, England
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 6, volume: 7, anno: 2001,
pagine: 535 - 543
SICI:
1355-4786(200111/12)7:6<535:TEORAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; INDUCED OVARIAN FAILURE; TOTAL-BODY IRRADIATION; LONG-TERM SURVIVORS; HIGH-DOSE BUSULFAN; HODGKINS-DISEASE; COMBINATION CHEMOTHERAPY; CYCLOPHOSPHAMIDE THERAPY; RADIATION-THERAPY; EARLY MENOPAUSE;
Keywords:
bone marrow transplantation; chemotherapy; fertility; ovarian transposition; radiotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Meirow, D Rabin Med Ctr, Dept Obstet & Gynecol, Tel Aviv, Israel Rabin MedCtr Tel Aviv Israel tet & Gynecol, Tel Aviv, Israel
Citazione:
D. Meirow e D. Nugent, "The effects of radiotherapy and chemotherapy on female reproduction", HUM REP UPD, 7(6), 2001, pp. 535-543

Abstract

High dose chemotherapy and radiotherapy have radically increased long-termsurvival of young cancer patients, but major side effects of these treatments are ovarian failure and infertility. Knowledge of the risks and probabilities of ovarian failure caused by treatment is crucial for patients and physicians in order to make informed choices that will best serve patients' interests. This review presents data on ovarian damage and failure following exposure to radiotherapy, chemotherapy and ablative therapy. The risk is evaluated from the published literature according to patient's age, treatment protocol and also according to the diagnosis of some common malignancies. Many of these patients will not be sterilized immediately following treatment, but will suffer from premature menopause. In order to prevent sterilization, ovarian transposition before pelvic irradiation is mandatory. Besides cryopreservation of ovarian tissue and embryos before administration of chemotherapy, the possible protective effect of pituitary-ovarian down-regulation is discussed. The mechanism of primordial follicles damage induced by radio/chemotherapy is presented as well as the role of apoptosis signalling pathways underlying destruction. Increased knowledge of these mechanismscould help to identify potential effective inhibitors that can block the path of primordial follicles destruction and reduce ovarian failure rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 21:52:44