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Titolo:
Are serum inhibin concentrations new markers of placental tumours in the course of chemotherapy?
Autore:
Pautier, P; Ghione, S; Brailly-Tabard, S; Lhomme, C; Morice, P; Bidart, JM;
Indirizzi:
Inst Gustave Roussy, Dept Med, Gynecol Unit, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Biol Clin, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Surg, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Hop Bicetre, Mol Biol & Hormonol Dept, F-94275 Le Kremlin Bicetre, France Hop Bicetre Le Kremlin Bicetre France F-94275 Le Kremlin Bicetre, France
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 11, volume: 16, anno: 2001,
pagine: 2434 - 2437
SICI:
0268-1161(200111)16:11<2434:ASICNM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; FREE BETA-SUBUNIT; MATERNAL SERUM; ACTIVIN-A; IMMUNOHISTOCHEMICAL LOCALIZATION; TROPHOBLASTIC NEOPLASIA; POSTMENOPAUSAL WOMEN; HYDATIDIFORM MOLE; EARLY-PREGNANCY; ALPHA;
Keywords:
human chorionic gonadotrophin; inhibin; marker; trophoblastic disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Pautier, P Inst Gustave Roussy, Dept Med, Gynecol Unit, F-94805 Villejuif,France Inst Gustave Roussy Villejuif France F-94805 illejuif, France
Citazione:
P. Pautier et al., "Are serum inhibin concentrations new markers of placental tumours in the course of chemotherapy?", HUM REPR, 16(11), 2001, pp. 2434-2437

Abstract

BACKGROUND: The study was conducted to evaluate whether the detection of serum molecular forms of inhibin (A and B) could be useful for the diagnosis, prognosis and follow-up of placental tumours. METHODS: A total of 17 patients with hydatidiform mole (n = 13), invasive mole (n = 1) or choriocarcinoma. (n = 3) were studied; serum concentrations of inhibins A and B, human chorionic gonadotrophin (HCG) and its free beta subunit (HCG beta) were measured before chemotherapy (after mole evacuation for eight patients) and also during the course of chemotherapy (for 10 patients). RESULTS: After evacuation or before chemotherapy for refractory disease, serum inhibin A and Bconcentrations were found to be increased in 10/17 and 4/17 patients, whenHCG and HCG beta were high in all patients. In 10 patients with a follow-up during treatment, nine had a high concentration of inhibin A which correlated with those of HCG and HCG beta. Normalization of inhibin A was faster than that of HCG and HCG beta for three and six patients respectively. There was no correlation between changes of inhibin B and HCG beta concentrations. CONCLUSIONS: Our results suggest that inhibins A and B are not useful markers and that HCG determination still remains the most useful marker for diagnosis and follow-up of placental tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:26:46