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Titolo:
Thrombotic thrombocytopenic purpura: prospective neurologic, neuroimaging and neurophysiologic evaluation
Autore:
Meloni, G; Proia, A; Antonini, G; De Lena, C; Guerrisi, V; Capria, S; Trisolini, SM; Ferrazza, G; Sideri, G; Mandelli, F;
Indirizzi:
Univ La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, I-00161 Rome,Italy Univ La Sapienza Rome Italy I-00161 llulari & Ematol, I-00161 Rome,Italy Univ La Sapienza, Dipartimento Sci Neurol, I-00161 Rome, Italy Univ La Sapienza Rome Italy I-00161 ento Sci Neurol, I-00161 Rome, Italy
Titolo Testata:
HAEMATOLOGICA
fascicolo: 11, volume: 86, anno: 2001,
pagine: 1194 - 1199
SICI:
0390-6078(200111)86:11<1194:TTPPNN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOLYTIC-UREMIC SYNDROME; NONCONVULSIVE STATUS EPILEPTICUS; FACTOR-CLEAVING PROTEASE; MRI; BRAIN; INVOLVEMENT; MANAGEMENT; CT;
Keywords:
thrombotic thrombocytopenic purpura; neurologic involvement; neuroimaging; EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Meloni, G Univ La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, ViaBenevento6, I-00161 Rome, Italy Univ La Sapienza Via Benevento 6 Rome Italy I-00161 Rome, Italy
Citazione:
G. Meloni et al., "Thrombotic thrombocytopenic purpura: prospective neurologic, neuroimaging and neurophysiologic evaluation", HAEMATOLOG, 86(11), 2001, pp. 1194-1199

Abstract

Background and Objectives. Neurologic symptoms are present in 60% of patients with thrombotic thrombocytopenic purpura (TTP) on initial examination and ultimately develop in about 90% of cases during the course of the disease. Despite central nervous system involvement being frequent, abnormalitiesin the brain of patients with TTP are infrequent on neuroimaging (CT/MRI) and neurophysiologic (EEG) evaluation, often reversible and mainly limited to symptomatic stages of the disease. The aim of our study was to establishthe value of a complete neurologic screening as part of the work up of TIPDesign and Methods. We prospectively evaluated 16 TTP patients, performingserial neurologic, neuroimaging and EEG examinations, independently of thepresence of an objective central nervous system involvement. Results. Our study shows that a complete neurologic evaluation is of modest help in improving the diagnosis of TTP, but may be useful for the neurologic management. Interpretation and Conclusions. Accurate neuroimaging and, especially, EEGevaluation and monitoring allowed us to identify patients who could benefit from anticonvulsive therapy, avoiding the unnecessary administration of the latter. The prognostic utility of complete neurologic screening in TTP remains to be conclusively demonstrated in larger prospective neurologic studies. (C) 2001, Ferrata Storti Foundation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:21:17