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Titolo:
A short pseudoautosomal region in laboratory mice
Autore:
Perry, J; Palmer, S; Gabriel, A; Ashworth, A;
Indirizzi:
Inst Canc Res, Breakthrough Toby Robins Breast Canc Res Ctr, London SW3 6JB, England Inst Canc Res London England SW3 6JB nc Res Ctr, London SW3 6JB, England
Titolo Testata:
GENOME RESEARCH
fascicolo: 11, volume: 11, anno: 2001,
pagine: 1826 - 1832
SICI:
1088-9051(200111)11:11<1826:ASPRIL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SEX-CHROMOSOMES; STEROID SULFATASE GENE; ESCAPES X-INACTIVATION; ALPHA-SUBUNIT GENE; GENOMIC STRUCTURE; TURNER-SYNDROME; HIGH-FREQUENCY; SHORT STATURE; Y-CHROMOSOME; MOUSE GENOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Ashworth, A Inst Canc Res, Breakthrough Toby Robins Breast Canc Res Ctr, London SW3 6JB, England Inst Canc Res London England SW3 6JB London SW3 6JB, England
Citazione:
J. Perry et al., "A short pseudoautosomal region in laboratory mice", GENOME RES, 11(11), 2001, pp. 1826-1832

Abstract

The pseudoautosomal region (PAR) of mammalian sex chromosomes is a small region of sequence identity that is the site of an obligatory pairing and recombination event between the X and Y chromosomes during male meiosis. During female meiosis, X chromosomes can pair and recombine along their entire length; recombination in the PAR is therefore similar to 10x greater in male meiosis compared with female meiosis. A consequence of the presence of the PAR in two copies in males and females is that genes in the region escapethe process of X-Inactivation. Although the structure and gene content of the human PAR at Xq/Yq is well understood, the mouse PAR, which appears to be of independent evolutionary origin, is poorly characterized. Here we describe a yeast artificial chromosome (YAC) contig covering the distal part of the Mouse X chromosome, which we have used to define the pseudoautosomal boundary, that is, the point of divergence of X-specific and X-Y-identical sequences. In addition, we have investigated the size of the mouse PAR by integrating a unique restriction endonuclease recognition site just proximalto the pseudoautosomal boundary by homologous recombination. Restriction digestion of this modified DNA and pulsed field gel electrophoresis reveal that the PAR in these cells is similar to 700 kb. Thus, the Mouse PAR, although small in size, has retained essential sex chromosome pairing functions despite its rapid rate of evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:00:12