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Titolo:
The role of integrins in human embryo implantation
Autore:
Merviel, P; Challier, JC; Carbillon, L; Foidart, JM; Uzan, S;
Indirizzi:
Hop Tenon, Serv Gynecol Obstet & Med Reprod, F-75020 Paris, France Hop Tenon Paris France F-75020 bstet & Med Reprod, F-75020 Paris, France
Titolo Testata:
FETAL DIAGNOSIS AND THERAPY
fascicolo: 6, volume: 16, anno: 2001,
pagine: 364 - 371
SICI:
1015-3837(200111/12)16:6<364:TROIIH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; HUMAN TROPHOBLAST; EXTRACELLULAR-MATRIX; HUMAN ENDOMETRIUM; MENSTRUAL-CYCLE; HUMAN CYTOTROPHOBLAST; SIGNAL-TRANSDUCTION; EXPRESSION; INVASION; KINASE;
Keywords:
endometrium; implantation window; implantation; integrins; trophoblast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Merviel, P Hop Tenon, Serv Gynecol Obstet & Med Reprod, 4 Rue Chine, F-75020 Paris, France Hop Tenon 4 Rue Chine Paris France F-75020 75020 Paris, France
Citazione:
P. Merviel et al., "The role of integrins in human embryo implantation", FETAL DIAGN, 16(6), 2001, pp. 364-371

Abstract

Integins are adhesion molecules present in endometrial, decidual, and extravillous cytotrophoblast (EVCT) cells. They participate in cell-cell adhesion as well as in adhesion between cells and components of the extracellularmatrix, and they play an important role in the endometrial phenotype change that occurs during the secretory phase, the first stage of implantation. At the beginning of pregnancy, the change in integrin expression is synchronized with the trophoblast attachment (embryo-endometrium interactions withintegrins alphav beta3, alpha4 beta1, alpha6 beta1, and alpha7 beta1) and the embryo's invasion of the deck dua (integrins alpha6 beta4 --> alpha5 beta1 --> alpha1 beta1 --> alpha4 beta1 switch from proliferative to endovascular EVCT). Several diseases, including preeclampsia, intrauterine growth retardation caused by vascular problems and defective luteal phases, may be explained by anomalies in integrin patterns. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:06:34