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Titolo:
Mesothelial cell-associated hyaluronic acid promotes adhesion of endometrial cells to mesothelium
Autore:
Dechaud, H; Witz, CA; Montoya-Rodriguez, IA; Degraffenreid, LA; Schenken, RS;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 & Infertil, San Antonio, TX 78229 USA Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 , Dept Med, San Antonio, TX 78229 USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 5, volume: 76, anno: 2001,
pagine: 1012 - 1018
SICI:
0015-0282(200111)76:5<1012:MCHAPA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; CANCER-CELLS; EXPRESSION; CD44; INTEGRINS; MODEL; PERITONEUM; MOLECULES; IL-1-BETA; CULTURE;
Keywords:
hyaluronic acid; hyaluronidase; peritoneum; mesothelium; endometrium; endometriosis; CD44; cell culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Witz, CA Univ Texas, Hlth Sci Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Mail Code 7836,7703 Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas Mail Code 7836,7703 Floyd Curl Dr San Antonio TX USA 78229
Citazione:
H. Dechaud et al., "Mesothelial cell-associated hyaluronic acid promotes adhesion of endometrial cells to mesothelium", FERT STERIL, 76(5), 2001, pp. 1012-1018

Abstract

Objective: To evaluate the role of hyaluronic acid in the attachment of endometrial cells to mesothelium. Design: In vitro study of adhesion of endometrial stromal and epithelial cells to mesothelial cells. Setting: University medical center. Patient(s): Reproductive-age women without endometriosis undergoing surgery for benign conditions. Intervention(s): None. Main outcome measure(s): The effect of hyaluronidase treatment of mesothelial cells or endometrial cells on adhesion of Cr-51 labeled endometrial stromal and epithelial cells to monolayers of mesothelium was evaluated. The expression of CD44, the hyaluronate receptor, was evaluated by western blot. Result(s): Hyaluronidase pretreatment of mesothelial cells decreased the binding of endometrial stromal and epithelial cells to mesothelium by 39% (P< .02) and 31% (P < 03), respectively. There was no effect on endometrial cell binding to mesothelial cells or to collagen IV when the endometrial cells were pretreated with hyaluronidase. CD44 expression by endometrial stromal and epithelial cells was demonstrated by western blot. Conclusions: This study demonstrates that mesothelial cell-associated hyaluronic acid is involved in attachment of endometrial stromal and endometrial epithelial cells to the mesothelium. We hypothesize that binding of hyaluronic acid by endometrial cells is involved in the pathogenesis of the early endometriotic lesion. (C) 2001 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:06:09