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Titolo:
Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic rats
Autore:
Tonra, JR; Cliffer, KD; Carson, SR; Lindsay, RM; Bodine, SC; DiStefano, PS;
Indirizzi:
Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA Regeneron Pharmaceut Inc Tarrytown NY USA 10591 , Tarrytown, NY 10591 USA
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 172, anno: 2001,
pagine: 220 - 227
SICI:
0014-4886(200111)172:1<220:RIHRIS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBER SENSORY NEUROPATHY; PERIPHERAL NEUROPATHY; NERVE-CONDUCTION; AUTONOMIC NEUROPATHY; TEMPORAL DISPERSION; MELLITUS; INSULIN; NEUROPEPTIDES; MUSCLES; BIOPSY;
Keywords:
diabetes; muscle atrophy; neuropathy; STZ; tendon reflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Tonra, JR Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY USA 10591
Citazione:
J.R. Tonra et al., "Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic rats", EXP NEUROL, 172(1), 2001, pp. 220-227

Abstract

In addition to reduced nerve conduction velocity, diabetic neuropathic patients often exhibit a reduction in the amplitude of the compound muscle action potential elicited by stimulation of the la-afferent-mediated reflex pathway (Hoffman or H wave) that can contribute to diminished or absent tendon reflexes. In contrast to nerve conduction velocity deficits, changes in H-wave amplitudes have not been reproduced in diabetic animal models. Using electrophysiological techniques developed for repeated recordings in individual animals, we report H-wave deficits in streptozotocin (STZ)-treated insulin-dependent diabetic rats. After 4 weeks of diabetes induced by STZ treatment, a 47% reduction in the H-wave amplitude was demonstrated by recording compound muscle action potentials in foot muscles after stimulation of laafferents. Interestingly, we also demonstrate that the H-wave amplitude gradually recovers to a 26% deficit after 12 weeks of experimental diabetes. The recovery of the H wave in STZ-treated rats distinguishes this deficit mechanistically from other STZ-induced electrophysiological changes and may model a similar recovery of the H wave reported in diabetic patients. (C) 2001 Academic Press.

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Documento generato il 04/07/20 alle ore 23:15:17