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Titolo:
Influence of bone marrow graft lymphocyte subsets on outcome after HLA-identical sibling transplants
Autore:
Rocha, V; Carmagnat, MV; Chevret, S; Flinois, O; Bittencourt, H; Esperou, H; Garnier, F; Ribaud, P; Devergie, A; Socie, G; DalCortivo, L; Marolleau, JP; Charron, D; Gluckman, E; Rabian, C;
Indirizzi:
Hop St Louis, Bone Marrow Transplant Unit, F-75475 Paris 10, France Hop StLouis Paris France 10 w Transplant Unit, F-75475 Paris 10, France Hop St Louis, Immunol Histocompatibil Lab, F-75475 Paris, France Hop St Louis Paris France F-75475 ocompatibil Lab, F-75475 Paris, France Hop St Louis, INSERM, U396, F-75475 Paris 10, France Hop St Louis Paris France 10 uis, INSERM, U396, F-75475 Paris 10, France Hop St Louis, Dept Biostat, F-75475 Paris 10, France Hop St Louis Paris France 10 uis, Dept Biostat, F-75475 Paris 10, France Hop St Louis, Cellular Therapy Lab, F-75475 Paris 10, France Hop St LouisParis France 10 lular Therapy Lab, F-75475 Paris 10, France
Titolo Testata:
EXPERIMENTAL HEMATOLOGY
fascicolo: 11, volume: 29, anno: 2001,
pagine: 1347 - 1352
SICI:
0301-472X(200111)29:11<1347:IOBMGL>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; RISK ACUTE-LEUKEMIA; APLASTIC-ANEMIA; STEM-CELLS; ALLOGENEIC TRANSPLANTATION; DONOR MARROW; CD8 CELLS; T-CELLS; REJECTION; PREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Rocha, V Hop St Louis, Clin Res Unit, Pavillon Lailler,1 Av Claude, F-75475 Paris 10, France Hop St Louis Pavillon Lailler,1 Av Claude Paris France 10 France
Citazione:
V. Rocha et al., "Influence of bone marrow graft lymphocyte subsets on outcome after HLA-identical sibling transplants", EXP HEMATOL, 29(11), 2001, pp. 1347-1352

Abstract

Objective. The aim of this study was to analyze bone marrow lymphocyte subsets and CD34 cell dose and their influence on the outcomes of bone marrow transplantation. Materials and Methods. Forty-eight patients (median age 30 years, range 5-54) receiving HLA-identical sibling bone marrow transplantation for hematologic malignancies were analyzed. Results. Median number (range) of nucleated cells and CD34(+) cells infused were 2.4 (0.4-6.0) x 10(8)/kg and 3.5 (0.5-13.0) x 10(6)/kg, respectively. Probability of neutrophil recovery was 97%. In a multivariate analysis, time to neutrophil recovery was shortened when a higher number of CD3/CD8 cells was infused (greater than or equal to1.0 x 10(7)/kg) (hazard ratio [HR]= 2.13, p = 0.018); when the patient was female or had negative cytomegalovirus serology (HR = 2.03, p = 0.03; HR = 0.41, p = 0.009; respectively). The incidence of grade II to IV acute graft-vs-host disease (GVHD) was 47%. Infusion of >1 x 10(7) CD4 infused/kg increased the risk of acute GVHD (HR = 2.86, p = 0.03). Nineteen of 40 patients at risk experienced chronic GVHD, the risk of which was increased by diagnosis of chronic leukemia (p = 0.03), <2.0 x 10(8) nucleated cells infused/kg (p = 0.05), and a low number ofall lymphocyte subsets, except CD19. Estimated 3-year survival rate was 54%. Risk of death was increased in patients receiving <3.5 x 10(6) CD34 infused/kg (HR = 0.37, p = 0.02). Only six patients relapsed. Conclusions. A high cell dose of CD3/CD8 is associated with faster neutrophil recovery, whereas a high cell dose of CD4(+) cells increases the incidence of acute GVHD. A high number of nucleated cells and CD34(+)cells infused was associated with decreased risk of chronic GVHD and improved survival,respectively. (C) 2001 International Society for Experimental Hematology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:07:37