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Titolo:
Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in clocultures of malignant oral squamous cell carcinoma cells anddermal fibroblasts
Autore:
Bair, EL; Massey, CP; Tran, NL; Borchers, AH; Heimark, RL; Cress, AE; Bowden, GT;
Indirizzi:
Univ Arizona, Grad Program, Canc Biol Interdisciplinary Program, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 sciplinary Program, Tucson, AZ 85724 USA Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85724 USA Univ Arizona TucsonAZ USA 85724 Dept Radiat Oncol, Tucson, AZ 85724 USA Univ Arizona, Dept Surg, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Arizona, Dept Surg, Tucson, AZ 85724 USA ISIS Pharmaceut, Dept Bioinformat, Carlsbad, CA 92008 USA ISIS PharmaceutCarlsbad CA USA 92008 Bioinformat, Carlsbad, CA 92008 USA
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 2, volume: 270, anno: 2001,
pagine: 259 - 267
SICI:
0014-4827(20011101)270:2<259:IACIOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PROSTATE CARCINOMA; N-CADHERIN; EXTRACELLULAR-MATRIX; 72-KDA GELATINASE; TISSUE INHIBITOR; EXPRESSION; ADHESION; COLLAGENASE; INVASION; TUMOR;
Keywords:
matrilysin; MMP-7; squamous cell carcinoma; matrix metalloprotease; SCC-25;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bowden, GT 1515 N Campbell Ave, Tucson, AZ 85724 USA 1515 N Campbell Ave Tucson AZ USA 85724 , Tucson, AZ 85724 USA
Citazione:
E.L. Bair et al., "Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in clocultures of malignant oral squamous cell carcinoma cells anddermal fibroblasts", EXP CELL RE, 270(2), 2001, pp. 259-267

Abstract

Matrilysin is a matrix metalloprotease (MMP) overexpressed in a number of cancers including skin, head and neck squamous cell carcinomas, and prostate and colon adenocarcinomas. Matrilysin has been shown to play a role in the degradation of the basement membrane that separates epithelium from stroma allowing tumor cells to intravasate into the bloodstream and metastasize. Here, we show that an oral squamous cell carcinoma cell line (SCC-25) expresses low levels of promatrilysin when cultured alone. However, when SCC-25cells are cocultured with human foreskin fibroblasts (HFF), there is a 40-fold induction of promatrilysin expression. We tested whether this induction of promatrilysin expression was due to the release of paracrine factors, cell-cell interactions, or cell-matrix interactions. Our results indicate induced promatrilysin expression is the result of both cell-cell and cell-matrix interactions. We demonstrate that beta1 integrins as well as cadherins, specifically N-cadherin and E-cadherin, are involved in the induction of promatrilysin expression. Our results are of general interest in relation to the regulation of NMP expression through cell surface receptor regulation. Further investigation may lead to the identification of novel targets forsuppression of invasion and metastasis in oral tumors. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:28:10