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Titolo:
Quetiapine: efficacy and tolerability in schizophrenia
Autore:
Kasper, S; Tauscher, J; Heiden, A;
Indirizzi:
Univ Vienna, Dept Gen Psychiat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Gen Psychiat, A-1090 Vienna, Austria
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
, volume: 11, anno: 2001, supplemento:, 4
pagine: 405 - 413
SICI:
0924-977X(200110)11:<405:QEATIS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; OLANZAPINE TRIAL; HALOPERIDOL; RISPERIDONE; PLACEBO; MULTICENTER; SEROQUEL; ANTIPSYCHOTICS; CHLORPROMAZINE; ICI-204,636;
Keywords:
quetiapine; schizophrenia; atypical antipsychotic; serotonin antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Kasper, S Univ Vienna, Dept Gen Psychiat, Waehringer Guertel 18-20, A-1090Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 tria
Citazione:
S. Kasper et al., "Quetiapine: efficacy and tolerability in schizophrenia", EUR NEUROPS, 11, 2001, pp. 405-413

Abstract

Quetiapine, in common with clozapine, has a greater affinity for 5-HT2 receptors than D-2 receptors and preclinical studies have consistently predicted efficacy against schizophrenia, with a low potential for causing extrapyramidal symptoms (EPS). In clinical trials, the efficacy of quetiapine was consistently superior to placebo and it was effective against both positiveand negative symptoms, Quetiapine was also at least as effective as chlorpromazine or haloperidol in improving the symptoms of acute schizophrenia and moreover was associated with higher response rates. The consistent, placebo-level incidence of EPS associated with quetiapine in clinical trials wasnot seen with haloperidol. Thus, the combination of efficacy comparable toother antipsychotic agents, with an acceptable side effect and tolerability profile, provides support for the use of quetiapine as a first-line antipsychotic agent in the long-term treatment of schizophrenia. (C) 2001 Elsevier Science BY All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:48:21