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Titolo:
Physical characterization of naproxen sodium hydrate and anhydrate forms
Autore:
Di Martino, P; Barthelemy, C; Palmieri, GF; Martelli, S;
Indirizzi:
Univ Camerino, Fac Pharm, Dept Chem Sci, I-62032 Camerino, Italy Univ Camerino Camerino Italy I-62032 t Chem Sci, I-62032 Camerino, Italy Univ Lille 2, Fac Pharmaceut & Biol Sci, F-59006 Lille, France Univ Lille 2 Lille France F-59006 ceut & Biol Sci, F-59006 Lille, France
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 4, volume: 14, anno: 2001,
pagine: 293 - 300
SICI:
0928-0987(200112)14:4<293:PCONSH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLIDS; MONOHYDRATE;
Keywords:
naproxen sodium; pseudopolymorphism; hydration/dehydration mechanism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Di Martino, P Univ Camerino, Fac Pharm, Dept Chem Sci, Via S Agostino, I-62032 Camerino,Italy Univ Camerino Via S Agostino Camerino Italy I-62032 o,Italy
Citazione:
P. Di Martino et al., "Physical characterization of naproxen sodium hydrate and anhydrate forms", EUR J PH SC, 14(4), 2001, pp. 293-300

Abstract

Naproxen sodium (NS) is a nonsteroidal anti-inflammatory drug used in painful and inflammatory diseases. By crystallization from water or by exposureto relative humidities over 43%, the anhydrate form can be hydrated to a dihydrate species. Different techniques have been used to characterize physically anhydrate naproxen sodium (ANS) and hydrate naproxen sodium (HNS): elemental analysis, atomic absorption, electron scanning microscopy, thermomicroscopy, differential scanning calorimetry, Karl Fisher's titrimetry, thermogravimetry, spectrophotometric analysis and X-ray diffraction study. The hydration/dehydration mechanism, at different relative humidities, was investigated to evaluate their physical stability. When stored up to 43% relative humidity, ANS shows a good stability, whereas with an increase in relative humidity it is hydrated. HNS equilibrium solubility was determined at different temperatures (21, 26, 31, and 37 degreesC). Due to the metastability and the quick phase changes in the water of ANS, its solubility was calculated from intrinsic dissolution measurements at the same temperatures, as solubility measurements of HNS. Water solubility of ANS is greater than HNS, but the solubility difference decreases when the temperature decreases. This is due to the fact that at higher temperatures the intrinsic dissolution rates (DDR) of ANS are considerably faster and decrease as the temperature falls. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:52:03