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Titolo:
Insulin promotes functional induction of silent synapses in differentiating rat neocortical neurons
Autore:
Plitzko, D; Rumpel, S; Gottmann, K;
Indirizzi:
Ruhr Univ Bochum, Lehrstuhl Zellphysiol, D-44780 Bochum, Germany Ruhr UnivBochum Bochum Germany D-44780 physiol, D-44780 Bochum, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 14, anno: 2001,
pagine: 1412 - 1415
SICI:
0953-816X(200110)14:8<1412:IPFIOS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC PLASTICITY; AMPA RECEPTORS; LTP; EXPRESSION; MATURATION; GABA(A); CALCIUM; CORTEX; NMDA; CNS;
Keywords:
AMPA receptors; glutamatergic synapses; NMDA receptors; synaptic plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Gottmann, K Ruhr Univ Bochum, Lehrstuhl Zellphysiol, D-44780 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44780 4780 Bochum, Germany
Citazione:
D. Plitzko et al., "Insulin promotes functional induction of silent synapses in differentiating rat neocortical neurons", EUR J NEURO, 14(8), 2001, pp. 1412-1415

Abstract

Long-term synaptic plasticity is thought to underlie synaptic reorganization phenomena that occur during neocortical development. Recently, it has been proposed, that the functional induction of AMPA receptors at silent glutamatergic synapses is of major importance in activity-dependent, developmental plasticity. To investigate the mechanisms involved in the developmentalregulation of silent synapses, we analysed the functional maturation of the thalamocortical projection in culture. A large proportion of the thalamocortical synapses were functionally silent at an early stage in vitro. During further differentiation, the incidence of silent synapses decreased drastically, indicating a conversion of silent into functional synapses. Chronicblockade of spontaneous network activity by addition of tetrodotoxin to the culture medium strongly impaired this developmental maturation. Moreover,the developmental decline in the proportion of silent synapses was dramatically accelerated by chronic addition of the neurotrophic factor, insulin. This effect of insulin was partly dependent on spontaneous activity. Thus, insulin appears to be involved in the modulation of long-term developmentalplasticity at immature glutamatergic synapses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:37:21