Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Unilateral striatal dopamine depletion: time-dependent effects on corticalfunction and behavioural correlates
Autore:
Steiner, H; Kitai, ST;
Indirizzi:
Univ Tennessee, Dept Anat & Neurobiol, Coll Med, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 biol, Coll Med, Memphis, TN 38163 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 14, anno: 2001,
pagine: 1390 - 1404
SICI:
0953-816X(200110)14:8<1390:USDDTE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENE; MESSENGER-RNA EXPRESSION; VENTROMEDIAL THALAMIC NUCLEUS; BASAL GANGLIA DISORDERS; SUBSTANTIA-NIGRA; 6-HYDROXYDOPAMINE LESIONS; RAT-BRAIN; C-FOS; VENTRAL STRIATUM; CATECHOLAMINE INNERVATION;
Keywords:
basal ganglia; c-fos; cortex; nigrostriatal; rat; striatum; zif 268;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Steiner, H Finch Univ Hlth Sci Chicago Med Sch, Dept Mol & Cellular Pharmacol, 3333 Green Bay Rd, N Chicago, IL 60064 USA Finch Univ Hlth Sci ChicagoMed Sch 3333 Green Bay Rd N Chicago IL USA 60064
Citazione:
H. Steiner e S.T. Kitai, "Unilateral striatal dopamine depletion: time-dependent effects on corticalfunction and behavioural correlates", EUR J NEURO, 14(8), 2001, pp. 1390-1404

Abstract

Previously, we showed that unilateral blockade of D1 dopamine receptors inthe striatum inhibits immediate-early gene expression bilaterally throughout large parts of the cortex, including sensory-evoked expression in the barrel cortex. To further investigate this dopamine regulation of cortical function, we examined the effects of dopamine depletion on cortical gene regulation and behavioural correlates. Two days after unilateral infusion of 6-hydroxydopamine into the midbrain, rats displayed a (to some degree) bilateral reduction in cortical zif 268 expression that was more pronounced on the lesioned side. This decrease was found across motor, somatosensory, insular and piriform, but not cingulate, cortex, similar to the effects of blockade of striatal D1 receptors, Furthermore, whisker stimulation-evoked c-fosand zif 268 expression in the barrel cortex ipsilateral to the lesion was also attenuated by acute dopamine depletion. These cortical deficits were accompanied by a breakdown of spontaneous behaviours in an open-field test. In contrast, 21 days after dopamine depletion, both basal and sensory-evoked gene expression in the cortex were near-normal. This cortical recovery was paralleled by recovery in locomotion and in sensory-guided behaviour (scanning) related to the hemisphere contralateral to the lesion, but not in scanning by the dopamine-depleted hemisphere. Our results suggest that striatal dopamine exerts a widespread facilitatory influence on cortical functionthat is necessary, but not sufficient, for normal behaviour. Moreover, themechanisms mediating this cortical facilitation appear to be subject to substantial neuroplasticity after dopamine perturbation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:37:54