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Titolo:
Catalepsy induced by a blockade of dopamine D-1 or D-2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of rats
Autore:
Hauber, W; Neuscheler, P; Nagel, J; Muller, CE;
Indirizzi:
Univ Stuttgart, Dept Anim Physiol, Inst Biol, D-70550 Stuttgart, Germany Univ Stuttgart Stuttgart Germany D-70550 iol, D-70550 Stuttgart, Germany Univ Bonn, Inst Pharmaceut, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 onn, Inst Pharmaceut, D-5300 Bonn, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 14, anno: 2001,
pagine: 1287 - 1293
SICI:
0953-816X(200110)14:8<1287:CIBABO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; HALOPERIDOL-INDUCED CATALEPSY; 6-HYDROXYDOPAMINE-LESIONED RATS; BASAL GANGLIA; GLOBUS-PALLIDUS; ROTATIONAL BEHAVIOR; PARKINSONS-DISEASE; TURNING BEHAVIOR; ANTAGONIST; STRIATUM;
Keywords:
A(2A) receptor antagonist; A(2A)/D-2 interaction; MSX-3; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Hauber, W Univ Stuttgart, Dept Anim Physiol, Inst Biol, D-70550 Stuttgart,Germany Univ Stuttgart Stuttgart Germany D-70550 50 Stuttgart, Germany
Citazione:
W. Hauber et al., "Catalepsy induced by a blockade of dopamine D-1 or D-2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of rats", EUR J NEURO, 14(8), 2001, pp. 1287-1293

Abstract

The present study sought to determine, in more detail, the effects of an unselective and a selective adenosine A(2A) receptor blockade on catalepsy induced by a blockade of dopamine D-1 or D-2 receptors in rats. The results demonstrated that systemic administration of the unselective A(1)/A(2) receptor antagonist, theophylline and the selective A(2A) receptor antagonist, CSC potently reversed catalepsy induced by a systemic D-2 receptor blockadewith raclopride or by a bilateral blockade of D-2 receptors in the caudate-putamen (CPu) with S(-)sulpiride. Likewise, systemic administration of theophylline and CSC reversed catalepsy induced by a systemic D-1 receptor blockade with SCH23390; theophylline also counteracted catalepsy after an intra-CPu D-1 receptor blockade with SCH23390. Intracerebral co-microinfusions of the selective A(2A) receptor antagonist, MSX-3 together with a D-1 (SCH23390) or D-2 receptor [S(-) sulpiride] antagonist revealed that catalepsy due to intra-CPu D-1 or D-2 receptor blockade can be potently reversed by anintra-CPu A(2A) receptor blockade. In conclusion, our results with systemic and intra-CPu drug administration demonstrate that D-1 and D-2 receptor-mediated catalepsy can both be reversed by a concomitant blockade of A(2A) receptors. Our results implicate that the CPu is a critical neural substratefor antagonistic interactions of a D-1/D-2 receptor blockade and an A(2A) receptor blockade in control of motor activity. The present results providefurther support for the view that A(2A) receptor antagonists may be potential therapeutics for the treatment of Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:32:21