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Titolo:
Ethanol reduces excitability in a subgroup of primary sensory neurons by activation of BKCa channels
Autore:
Gruss, M; Henrich, M; Konig, P; Hempelmann, G; Vogel, W; Scholz, A;
Indirizzi:
Univ Giessen, Inst Physiol, D-35385 Giessen, Germany Univ Giessen Giessen Germany D-35385 t Physiol, D-35385 Giessen, Germany Univ Giessen, Anaesthesiol & Operat Intens Med Abt, D-35390 Giessen, Germany Univ Giessen Giessen Germany D-35390 s Med Abt, D-35390 Giessen, Germany Univ Giessen, Inst Anat & Zellbiol, D-35390 Giessen, Germany Univ GiessenGiessen Germany D-35390 Zellbiol, D-35390 Giessen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 14, anno: 2001,
pagine: 1246 - 1256
SICI:
0953-816X(200110)14:8<1246:EREIAS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROOT GANGLION NEURONS; ACTION-POTENTIAL PROPAGATION; CA2+-ACTIVATED K+ CHANNELS; THIN SLICE PREPARATION; RAT SPINAL-CORD; POTASSIUM CHANNELS; LARGE-CONDUCTANCE; NERVOUS-SYSTEM; ION CHANNELS; ALCOHOL;
Keywords:
action potential; analgesia; calcium-activated potassium channel; dorsal root ganglion; paresthesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Scholz, A Univ Giessen, Inst Physiol, D-35385 Giessen, Germany Univ Giessen Giessen Germany D-35385 D-35385 Giessen, Germany
Citazione:
M. Gruss et al., "Ethanol reduces excitability in a subgroup of primary sensory neurons by activation of BKCa channels", EUR J NEURO, 14(8), 2001, pp. 1246-1256

Abstract

Ethanol effects on the central nervous system have been well investigated and described in recent years; modulations, by ethanol, of several ligand-gated and voltage-gated ion channels have been found. In this paper, we describe a shortening of action potential duration (APD) by ethanol in approximate to 40% of small diameter neurons in rat dorsal root ganglia (DRG). In these neurons, designated as group A neurons, we observed an ethanol-inducedincrease in whole-cell outward-current. As iberiotoxin, a specific blockerof large-conductance calcium-activated K+ channels (BKCa channels), blocksthe effects of ethanol, we investigated the interaction between these channels and ethanol in outside-out patches. Open probability of BKCa channels was increased 2-6 x depending on the concentration (40-80 mM approximate to2-4 parts per thousand v/v) of ethanol. Functional consequences were a prolongation of the refractory period, which was reversible after addition of iberiotoxin, and reduced firing frequency during ethanol application. In contrast, another type of neuron (group B) showed a prolonged APD during application of ethanol which was irreversible in most cases. In 90% of cases, neurons of group A showed a positive staining for isolectin B4 (I-B4), a marker for nociceptive neurons. We suggest that the activation of BKCa channels induced by clinically relevant concentrations of ethanol, the resulting modulations of APD and refractory period of DRG neurons, might contribute toclinically well-known ethanol-induced analgesia and paresthesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:35:34