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Titolo:
Postnatal maturation of GABA(A) and GABA(C) receptor function in the mammalian superior colliculus
Autore:
Boller, M; Schmidt, M;
Indirizzi:
Ruhr Univ Bochum, D-44780 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44780 Bochum, D-44780 Bochum, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 14, anno: 2001,
pagine: 1185 - 1193
SICI:
0953-816X(200110)14:8<1185:PMOGAG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; SYNAPTIC TRANSMISSION; RHO-SUBUNIT; RAT-BRAIN; IN-VITRO; PHARMACOLOGY; TRANSMITTER; INHIBITION; SLICES; SYSTEM;
Keywords:
extracellular field potential; GABAergic interneurons; patch-clamp; rat; stratum griseum superficiale (SGS); visual information processing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, M Ruhr Univ Bochum, D-44780 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44780 44780 Bochum, Germany
Citazione:
M. Boller e M. Schmidt, "Postnatal maturation of GABA(A) and GABA(C) receptor function in the mammalian superior colliculus", EUR J NEURO, 14(8), 2001, pp. 1185-1193

Abstract

In the stratum griseum superficiale (SGS) of the mammalian superior colliculus, GABA(C) receptors seem to control the excitability of projection neurons by selective inactivation of local GABAergic interneurons. As the onsetof visual responses to SC begins well after birth in the rat, it is possible to study developmental changes in GABAergic mechanisms that are linked to the onset of visual information processing. In order to analyse postnatalchanges in inhibitory mechanisms that involve GABA receptor function, we used extracellular field potential (FP) recordings and single cell patch-clamp techniques in slices from postnatal day 4 (P4) to P32 and examined the effects of GABA and muscimol on electrically evoked SGS cell activity. WhileGABA(A) receptor activation affected FP amplitudes throughout postnatal development, GABA(C) receptor activation did not significantly change FP amplitudes until the third postnatal week. Results from patch-clamping single cells, however, clearly demonstrate that GABA(C) receptors are already functional at P4 - similar to GABA(A) receptors. Throughout postnatal development, activation of GABA(C) receptors leads to a strong inhibition of inhibitory postsynaptic activity, indicating that GABA(C) receptors are expressed by inhibitory interneurons. Furthermore, the proportion of neurons that showdecreased excitatory postsynaptic activity during GABA(C) receptor activation correlates with the proportion of GABAergic interneurons in SGS. Our patch-clamp results indicate that the functional expression of GABA(C) receptors by GABAergic interneurons does not change significantly during postnatal development. However, our measurements of FP amplitudes indicate that thematuration of the efferent connections of these GABAergic neurons within SGS during the third postnatal week strongly changes GABA(C) receptor function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:53:46