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Titolo:
Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
Autore:
Otto, B; Cuntz, U; Fruehauf, E; Wawarta, R; Folwaczny, C; Riepl, RL; Heiman, ML; Lehnert, P; Fichter, M; Tschop, M;
Indirizzi:
Univ Hosp, Dept Med, Munich, Germany Univ Hosp Munich GermanyUniv Hosp, Dept Med, Munich, Germany Klin Roseneck, Psychosomat Clin, Prien Am Chiemsee, Germany Klin RoseneckPrien Am Chiemsee Germany lin, Prien Am Chiemsee, Germany Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & CoIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 5, volume: 145, anno: 2001,
pagine: R5 - R9
SICI:
0804-4643(200111)145:5<R5:WGDEPG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE SECRETAGOGUE; BODY-WEIGHT; EATING DISORDERS; GH SECRETION; LEPTIN; PEPTIDE; PROTEIN;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Otto, B Klinikum Univ Munchen, Med Klin Innenstadt, Ziemssenstr 1, D-80336Munich,Germany Klinikum Univ Munchen Ziemssenstr 1 Munich Germany D-80336ermany
Citazione:
B. Otto et al., "Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa", EUR J ENDOC, 145(5), 2001, pp. R5-R9

Abstract

Objective: Ghrelin is a new gastric hormone that has been identified as anendogenous ligand for the growth hormone (GH) secretagogue receptor subtype I a (GHS-R1a). Ghrelin administration however not only stimulates GH secretion but also induces adiposity in rodents by increasing food intake and decreasing fat utilization. We hypothesized that impaired ghrelin secretion in anorexia nervosa may be involved in the pathogenesis of this eating disorder. To examine this hypothesis and to further investigate the role for ghrelin in regulating energy homeostasis, we analyzed circulating ghrelin levels in patients with anorexia nervosa and examined possible correlations with clinical parameters before and after weight gain. Methods: Plasma ghrelin levels were measured in overnight fasting plasma samples from 36 female patients with anorexia nervosa (age: 25.0 +/-1.2 years, BIH: 15.2 +/-0.2 kg/m(2)) before and after weight gain following psychotherapeutic treatment intervention in a psychosomatic institution. Plasma ghrelin levels were also measured in fasting plasma samples from 24 age-matched female controls (31 +/-1.4 years, BMI: 22.9 +/-0.45 kg/m(2)). For quantification of ghrelin levels a commercially available radioimmunoassay (Phoenix Pharmaceuticals, USA) was used. Results: Fasting plasma ghrelin levels in anorectic patients were significantly higher (1057 +/- 95 pg/ml) than in normal age-matched female controls(514 +/- 63 pg/ml n=24, P=0.02). Therapeutic intervention in a psychosomatic institution caused an BMI increase of 14% (P < 0.001) leading to a significant decrease in circulating ghrelin levels of 25%, (P = 0.001). A significant negative correlation between Delta ghrelin and Delta BMI was observed(correlation coefficient: -0.47, P = 0.005, n = 36). Conclusion: We show for the first time that fasting plasma levels of the novel appetite-modulating hormone ghrelin are elevated in anorexia nervosa and return to normal levels after partial weight recovery. These observations suggest the possible existence of ghrelin resistance in cachectic states such as caused by eating disorders. Future studies are necessary to investigate putative mechanisms of ghrelin resistance such as a possible impairment of intracellular ghrelin receptor signaling in pathophysiological states presenting with cachexia.

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Documento generato il 29/11/20 alle ore 03:31:16