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Titolo:
Peripheral blood involvement in a mycosis fungoides patient with limited skin lesions: phenotypical features and homing molecule pattern
Autore:
Quaglino, P; Osella-Abate, S; Novelli, M; Lisa, F; Comessatti, A; Bernengo, MG;
Indirizzi:
Univ Turin, Dept Med & Surg Specialties, Dermatol Sect, Dermatol Clin 1, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 ct, Dermatol Clin 1, I-10126 Turin, Italy
Titolo Testata:
EUROPEAN JOURNAL OF DERMATOLOGY
fascicolo: 6, volume: 11, anno: 2001,
pagine: 560 - 563
SICI:
1167-1122(200111/12)11:6<560:PBIIAM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LYMPHOMA; PROGNOSTIC FACTORS; SEZARY-SYNDROME; EXPRESSION; LYMPHOCYTES; ANTIGEN;
Keywords:
homing molecules; mycosis fungoides; peripheral blood involvement; cutaneous T cell lymphoma prognosis; soluble interleukin-2 receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Bernengo, MG Univ Turin, Dept Med & Surg Specialties, Dermatol Sect, Dermatol Clin 1, Via Cherasco 23, I-10126 Turin, Italy Univ Turin Via Cherasco 23 Turin Italy I-10126 Turin, Italy
Citazione:
P. Quaglino et al., "Peripheral blood involvement in a mycosis fungoides patient with limited skin lesions: phenotypical features and homing molecule pattern", EUR J DERM, 11(6), 2001, pp. 560-563

Abstract

Peripheral blood involvement in mycosis fungoides (MF) patients is more frequent in the advanced stages and is associated with a worse prognosis. We report a MF patient with limited patch lesions on her shoulders, upper chest and thighs (T2N0M0) and peripheral blood involvement. Clonality in the peripheral blood was demonstrated by the PCR assay and confirmed by the expansion of the same restricted variable region of the TCR beta -chain (v beta 17) expressed in the cutaneous infiltrate. The patient was treated with fludarabine achieving a complete hematological response followed by an early relapse. whilst the cutaneous lesions remained unchanged. The soluble interleukin-2 receptor levels showed a decrease from baseline levels down to normal values at hematological remission, followed by a further increase. The low sLe(x)/CLA expression in the cutaneous lymphoid infiltrate could have given rise to a higher recruitment in the peripheral blood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:37:35